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  • Luteal Phase Sertraline and PMDD

    Synopsis: Sertraline was significantly more effective than placebo when taken during the luteal phase for PMDD.
  • Maternal Diabetes and Infant Malformations

    Synopsis: Women with pregestational diabetes or gestational diabetes plus fasting hyperglycemia have a 3- to 4-fold increased risk of infant malformations, whereas women with mild gestational diabetes have malformation rates no different than the general nondiabetic obstetric population.
  • The Insulin Resistance Syndrome — Syndrome X

    The quintet of abdominal obesity, hypertension, dyslipidemia, abnormal glucose metabolism, and coagulopathy has been called syndrome X or metabolic syndrome. Some have referred to this grouping as the insulin resistance syndrome, the obesity dyslipidemia syndrome, and the deadly quartet.
  • Preconception Care

    The primary care physician who cares for couples in their childbearing years should encourage women and their partners to receive preconception care. The physician can enhance this opportunity by adopting a preconception focus during annual medical exams and asking the patients about their conception plans.
  • Pharmacology Watch: FDA Approves Generic Version of AstraZeneca’s Prilosec

    FDA Approves Generic Version of AstraZenecas Prilosec; Pegasys Approved To Treat Hepatitis C; HRT Reduces Alzheimers Risk, Study Says; Heparin Plus Alteplase More Effective; Digoxin Effects Differ By Sex; McClellan Named FDA Commissioner; FDA Actions
  • Clinical Briefs in Primary Care Supplement

    Vitamin-Mineral Supplementation and Acute RTI in Elderly; B-Type Natriuretic Peptide Levels and Outcome in Heart Failure; Companion Influence During Primary Care Encounters; Handrubbing with Alcohol-Based Solution vs. Standard Handwashing; Program To Prevent Functional Decline in Frail Elderly Who Live at Home; Treatment of Diabetic Neuropathy with Isosorbide Dinitrate Spray
  • Identifying and Treating Seizures and Epilepsy

    A seizure is an abnormal, hypersynchronous discharge of a population of cortical neurons that may be associated with clinical manifestations corresponding to the area of the brain involved. Epilepsy is a disorder of the central nervous system in which symptoms are 2 or more seizures greater than 24 hours apart, not provoked by another cause.
  • Fibrates, Statins, and Myopathy

    Fibrates and statins are associated with a 42-fold and 8-fold increased risk of myopathy, respectively, compared to normal controls, but the incidence remains low, at 6 per 100,000 and 1 per 100,000, respectively.
  • Warfarin vs Aspirin in AF: A Meta-Analysis

    Considerable concern exists among clinicians regarding the risk-benefit ratio of long-term anticoagulation compared to antiplatelet treatment. In order to compare the risk of vascular events and bleeding complications in patients with AF, van Walraven and associates analyzed data from 6 randomized clinical trials.
  • Do Dietary Antioxidants Prevent Alzheimer’s Disease?

    Three recent studies have provided epidemiologic data that increased intake of antioxidants may be associated with a reduced risk of developing AD.