Low levels of anti-Müllerian hormone in combination with an elevated day 2-3 follicle-stimulating hormone is associated with a high rate of aneuploid embryos.
A review of incident cases of venous thrombosis in women using oral contraceptives (OCs) in a U.S. insurance database found that use of drospirenone-containing OCs containing 20 ìg of ethinyl estradiol (EE) was associated with a two-fold increase in risk compared to levonorgestrel pills. This risk was not increased with use of 30 ìg EE drospirenone pills.
Selumetinib, a selective MEK1/2 inhibitor, achieved objective responses in 15% of patients with recurrent low-grade serous ovarian cancer (LGSOC). The data are relevant as this uncommon tumor type is associated with general chemoresistance, frequent aberration in the MAPK pathway, and prolonged overall survival compared with its more common high-grade variant. Phase 3 trials are planned.
In this randomized, controlled trial, tranexamic acid and mefanamic acid were no better than placebo in reducing the number of bleeding or spotting days in the first 3 months after LNG-IUS placement.
