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  • Pharmacology Update: Ospemifene Tablets (Osphena™)

    A selective estrogen receptor modulator (SERM), also known as an estrogen agonist/antagonist, has been approved by the FDA for the treatment of dyspareunia (painful intercourse) in postmenopausal women. Ospemifene is manufactured by Penn Pharmaceuticals Services Ltd. and marketed by Shionogi Inc. as Osphena.
  • Apixaban vs Warfarin for Atrial Fibrillation

    The authors concluded that in patients with AF, decreasing GFR was associated with a higher risk of cardiovascular events and bleeding. Apixaban as compared to warfarin reduced these risks regardless of renal function, with the greatest benefit seen in reducing major bleeding in those with impaired renal function.
  • Hepatitis B and C Screening

    Adults with private health care insurance in the United States have suboptimal testing for chronic hepatitis B virus (HBV) and hepatitis C virus (HCV). Clearly, increased awareness is needed regarding HBV and HCV infections, epidemiology, risk, and screening.
  • Contemporary Prevalence of Atherosclerosis in Military Personnel at Autopsy

    Among deployed U.S. service members who died of combat or unintentional injuries and received autopsies, the prevalence of atherosclerosis varied by age and cardiovascular risk factors.
  • Delayed Primary Epstein-Barr Virus Infection: Clinical and Immunologic Manifestations

    A prospective study on Epstein-Barr virus seronegative college freshmen found that primary infection was symptomatic in 89% of cases. Kissing was the primary risk factor for infection, and blood viral load, CD8+ lymphocytosis, and IL-6 levels correlated with disease severity.
  • Clinical Briefs By Louis Kuritzky, MD

    A More Effective Regimen for H. pylori Eradication; Uric Acid: How Much of a Bad Guy?; The Word GPR40 Modulator May Soon be Entering Our Vocabulary
  • Yoga in the Management of Chronic Low Back Pain — Not just for Yuppies

    he improvement in back pain and back-related function in this predominantly minority and low-income population was similar to prior studies looking at more affluent populations. here did not appear to be a dose response when comparing twice-weekly to once-weekly yoga classes, but this finding was confounded by a smaller than expected difference between the groups in the time spent in yoga practice and lack of reliable data on the amount of home practice. he study suggests that the greatest benefit may occur in the first 6 weeks of practice.
  • Obesity and Microbiota

    everal mechanisms by which the gut microbiota may contribute to obesity have been shown in animal studies. hort-chain fatty acids, prebiotics, and certain species of probiotics have been shown to affect the gut microbiota and reduce weight gain in animals subject to high-fat diet feeding. here are a few clinical trials showing beneficial aspects of prebiotics and probiotics on abdominal adiposity.
  • Do Certain Fruits Decrease the Risk of Type 2 Diabetes?

    ietary modifications among other lifestyle changes prevent development of type 2 diabetes. hole fruits contain more phytochemicals, fiber, and antioxidants, and thus more health benefits, than fruit juice. lueberries significantly decrease the risk of developing type 2 diabetes. ruit juice significantly increases the risk of developing type 2 diabetes.
  • Is Cardioversion After Acute Atrial Fibrillation Safe Without Anticoagulation?

    In clinical practice, patients with atrial fibrillation (AF) duration < 48 hours often undergo cardioversion without systemic anticoagulation.