Clinical
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Use of Coronary Calcium Score in Familial Coronary Artery Disease
A randomized trial of computed tomography (CT) coronary artery calcium score augmented management vs. usual care of primary prevention patients at moderate risk of a coronary event and with a family history of premature coronary events has shown that, after three years of follow-up, the calcium score group had lower low-density lipoprotein cholesterol levels and smaller total plaque volumes by CT angiography.
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Systolic Blood Pressure Targets in Octogenarians
An analysis of a U.S. national database of patients 80 years of age or older taking antihypertensive agents was analyzed to determine the optimal systolic blood pressure associated with the lowest cardiovascular mortality and found that the ideal target was < 130 mmHg.
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Long-Term NSAID Use May Lower Dementia Risk
In a prospective population-based study of nonsteroidal anti-inflammatory drugs, long-term use was associated with a reduced risk for dementia compared with short- and intermediate-term use.
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Beware Social Media Posts Promoting Medical Tests, Potential for Overdiagnosis
An analysis of widely viewed social media posts about five medical tests — full body magnetic resonance imaging, multicancer early detection, anti-Müllerian hormone, gut microbiome, and testosterone tests — found that 87.1% of the posts promoted benefits, while just 14.7% acknowledged potential harms and only 6.1% raised concerns about overuse or overdiagnosis.
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Systolic Blood Pressure Targets in Octogenarians
An analysis of a U.S. national database of patients 80 years of age or older taking antihypertensive agents was analyzed to determine the optimal systolic blood pressure associated with the lowest cardiovascular mortality and found that the ideal target was < 130 mmHg.
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Direct Oral Anticoagulants vs. Warfarin for Left Ventricular Thrombus
A small pilot randomized controlled trial, plus a meta-analysis including four other randomized controlled trials, of direct oral anticoagulants compared to warfarin for the treatment of left ventricular thrombus after ST-elevation myocardial infarction has shown that there were no significant differences in the two regimens regarding thrombus resolution and major bleeding events at three-month follow-up.
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The Cause of the ‘Burning?’
The electrocardiogram (ECG) in the figure is from a man with a new and severe “burning” chest discomfort. On seeing this ECG, the paramedic team requested activating the cath lab. Would you have done the same?
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Use of Coronary Calcium Score in Familial Coronary Artery Disease
A randomized trial of computed tomography (CT) coronary artery calcium score augmented management vs. usual care of primary prevention patients at moderate risk of a coronary event and with a family history of premature coronary events has shown that, after three years of follow-up, the calcium score group had lower low-density lipoprotein cholesterol levels and smaller total plaque volumes by CT angiography.
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Aztreonam and Avibactam for Injection (Emblaveo)
The U.S. Food and Drug Administration has approved a new combination antibiotic for the treatment of complicated intra-abdominal infections where there are limited or no alternative options.
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Death Due to the ‘No Name’ Virus in Santa Fe
On Feb. 26, 2025, it was announced that the bodies of actor Gene Hackman and his wife and caregiver Betsy Arakawa had been found in their Santa Fe, NM, home