Browse Clinical Publication Articles by Topic

Use Caution if Machine Learning Models Are Used to Predict Mortality

Machine learning and artificial intelligence will be part of caring for patients in some way or another going forward. Clinicians need to know what it all means and what the potential pitfalls are.

Ethical Controversy Persists Over Organ Procurement Method

Ethical debate continues over a controversial method of procuring organs for transplantation: Normothermic regional perfusion with controlled donation after circulatory determination of death.

Greater Awareness of Reporting Bias on Antidepressants, Yet Problem Persists

An investigator who was part of a landmark study on the efficacy of antidepressants recently revisited reporting transparency in this area of research.

Regarding Exercise Capacity Past Age 75 Years, What Is Normal?

A group of researchers delivered results that could help inform clinicians about the expected exercise test performance of older patients.

Detecting Cancer Treatment-Related Cardiac Dysfunction

When searching for breast cancer-related cardiac dysfunction, a sequential algorithm using echo ejection fraction and strain parameters produced an area under the receiver operating curve of 89%. Adding biomarkers did not improve the ability to diagnose cardiac dysfunction.

Comparing CT Angiography to Invasive Angiography for Stable Chest Pain Patients

A trial of initial coronary CT angiography vs. invasive angiography revealed outcomes over a median 3.5-year follow-up were similar, but procedure-related complications were more common in the invasive group.

Thrombolysis vs. Surgery for Thrombosed Mechanical Prosthetic Valves

A study of patients with obstructive prosthetic valve thrombosis that deployed low-dose, slow infusion thrombolysis or surgery using shared decision-making, showed thrombolysis was highly effective and resulted in fewer major complications than surgery.

Comparison of Treatments Highlights Poor Outcomes for TAVR Patients with Infective Endocarditis

In this analysis of a large registry of transcatheter aortic valve replacement patients with confirmed endocarditis, most were treated with antibiotics without surgery. In-hospital and one-year mortality rates were high and were not much better in patients who underwent surgery.

Donepezil Transdermal Patch (Adlarity)

Donepezil transdermal system can be prescribed to treat mild, moderate, and severe dementia of the Alzheimer’s type.

Bloodstream Infections During COVID-19

Severity of illness, prolonged hospital stays, use of mechanical ventilation, and use of immune-modulating agents in patients with COVID-19 may have contributed to observed increases in hospital-acquired blood stream infections and attendant mortality.