Browse Clinical Publication Articles by Topic

Metabolic Dysfunction-Associated Steatotic Liver Disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic metabolic disease that you may never have heard of. MASLD, formerly known as non-alcoholic fatty liver disease (NAFLD), is the most prevalent liver disease worldwide. MASLD affects 30% of the world’s population, more than half of those people with obesity, and more than 70% of people with type 2 diabetes. While many clinicians may see patients with slightly elevated transaminases and assume it is fatty liver, MASLD is not benign and often begins well before laboratory changes. This article reviews the pathogenesis, diagnosis, and natural history of MASLD; known treatments; and future therapies.

Sofpironium Topical Gel (Sofdra)

The U.S. Food and Drug Administration has approved a second topical anticholinergic product for the treatment of hyperhidrosis.

Enlargement of Choroid Plexus in Subacute COVID-19 Patients

The choroid plexus is a network of capillaries whose main role involves facilitating cerebrospinal fluid production and the exchange of nutrients and waste products between the central nervous system and the bloodstream. Immune cells are present near the choroid plexus. Enlargement of the choroid plexus has been noted in patients with multiple sclerosis.

Chlorthalidone vs. Hydrochlorothiazide for Hypertension

A subgroup analysis of those with prior myocardial infarction or ischemic stroke in the Diuretic Comparison Project for the treatment of hypertension has found that this higher-risk group experiences fewer major adverse cardiovascular events while taking chlorthalidone compared to hydrochlorothiazide, but at the expense of more hypokalemia.

TB Screening Dismayingly Low in Those at Risk

Screening for latent tuberculosis (TB) infection in persons at risk is woefully lax in our country — and yet, reactivation TB is such an eminently preventable disease.

Is It Past Time to Change Dietary Guidelines for Alcohol Use?

Analysis reveals that previous studies demonstrating the health benefits of moderate alcohol drinking were of low quality and that the relatively few published studies meeting the minimal quality criteria to avoid this problem do not show significantly lower mortality risk for moderate alcohol drinkers.

CSF Analysis May Help in the Diagnosis of Dementia with Lewy Bodies

This paper demonstrated that cerebrospinal fluid (CSF) alpha-synuclein seeding assays can distinguish between clinically diagnosed dementia with Lewy bodies and controls, and that the presence of hyposmia with core clinical features had the highest predictive value of detecting CSF alpha-synuclein.

Anchoring Alzheimer’s Disease Along an Amyloid Timeline

In 601 individuals from Wisconsin-based cohorts with amyloid-beta and tau positron emission tomography scans, the magnitude and topographical spread of tau pathology increased with longer duration of amyloid-beta positivity, and the cognitive decline was steepest in those with the longest duration of amyloid-beta positivity and elevated entorhinal tau.

Clinical Criteria for a Limbic-Predominant Amnestic Neurodegenerative Syndrome

Predominant limbic degeneration in older geriatric patients (ages 75 years and older) with slowly progressive episodic memory loss with fluorodeoxyglucose-positron emission tomography medial temporal hypometabolism limbic-predominant age-related TDP-43 encephalopathy (LATE) involves a progressive degeneration of the amygdala, then hippocampus, then middle frontal gyrus.

Can Large Vessel Strokes Be Treated with IV Thrombolysis in an Extended Time Window?

In this trial involving Chinese patients with ischemic stroke caused by large vessel occlusion, treatment with tenecteplase administered 4.5 to 24 hours after stroke onset resulted in less disability and similar survival compared to standard medical treatment.