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In this trial of cerebral protection in transcatheter aortic valve replacement, the TriGUARD device was safe vs. historical controls, but failed to meet its primary efficacy endpoint.
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An analysis demonstrated an inverse association of coffee consumption and cardiac arrhythmias, which was not altered by genetic variations in caffeine metabolism, age, or sex.
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An analysis of the UK Biobank database revealed low levels of alcohol consumption, especially with wine and spirits, is associated with the lowest incidence of atrial fibrillation.
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In a randomized trial of patients with atrial fibrillation, left atrial appendage occlusion during elective cardiac surgery was associated with lower rates of ischemic stroke or systemic embolism after 30 days.
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Giving intravenous ferric carboxymaltose to stabilized post-acute heart failure patients with iron deficiency improved quality of life vs. placebo-treated patients within four weeks, which persisted during subsequent therapy for up to 24 weeks.
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An analysis of the COMPASS trial for the secondary endpoint of mortality showed the combination of low-dose rivaroxaban and aspirin significantly lowered the all-cause mortality rate vs. low-dose aspirin alone.
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This analysis of mitral surgery after failed transcatheter edge-to-edge repair demonstrates high rates of valve replacement as opposed to repair. Surgical mortality was higher than predicted but was significantly lower in high-volume centers.
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An analysis of the ASPREE database showed that with almost five years of follow-up, statins are not associated with cognitive decline or dementia in a large group of elderly subjects in whom multiple tests of cognition were performed serially.
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But randomized trials are needed to better detail long-term risk-benefit ratio.
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After years of improvement in this area, investigators recently observed troubling decline in rate control.
