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In order to achieve new aggressive blood pressure goals in hypertensive patients, drug combinations are often used. But which combinations are superior for preventing cardiovascular events?
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Invasive coronary angiography (ICA) is the gold standard for assessment of epicardial coronary artery disease. There is much interest in non-invasive alternatives to ICA to assess coronary arteries in order to eliminate the complications associated with arterial access and catheter manipulation during ICA.
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Khan et al report a multicenter trial comparing pulmonary vein isolation vs AV junctional ablation with biventricular pacing in patients with atrial fibrillation and heart failure.
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The Microvolt t-wave Alternans Testing for risk Stratification of Post-Myocardial Infarction Patients (MASTER) trial tested the hypothesis that microvolt T-wave alternans (MTWA) testing could successfully predict arrhythmia occurrence in patients receiving an ICD for primary prevention of sudden cardiac death.
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The JUPITER trial causes a stir; ACP practice guideline for antidepressant use; testosterone for low libido; continued shortage of Hib vaccine; FDA Actions.
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JUPITER, a trial first presented november 9, 2008, at the american Heart Association meeting in New Orleans, was clearly "the bell of the ball," with multiple television, newspaper, and medical journal reports.
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The dramatic reduction in in-stent restenosis (ISR) afforded by drug-eluting stents (DES) led to their widespread use throughout the world. Subsequently, more patients and lesions could be treated percutaneously with less thought about ISR. With the advent of a more widespread adoption of percutaneous coronary intervention, registry data began suggesting an increased risk of late and very late stent thrombosis with DES compared to bare-metal stents (BMS).
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The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)-Prevenzione trial demonstrated a lower mortality rate in post myocardial infarction patients treated with n-3 polyunsaturated fatty acids (PUFA) vs controls, which was mainly due to a reduction in sudden death.
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In this paper, Adabag et al from the Mayo Clinic analyzed the risk of sudden death after an acute myocardial infarction over a 28-year period in patients residing in Olmsted County, MN.
