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The first retinoid as a topical foam has been approved by the FDA for the treatment of acne. Tazarotene is a synthetic, third-generation, polyaromatic, prodrug that binds to the retinoic acid receptors. Tazarotene is available in both gel and cream formulations. The foam is marketed by Stiefel as Fabior™.
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Unless a dramatic demographic shift occurs, approximately one in four of us will reside in a long-term care facility (LTCF) during our lifetime. Among LTCF residents, 30-50% of antibiotic utilization is for urinary tract infections (UTIs), resulting in substantial expense, adverse drug reactions, and ever-growing populations of resistant bacteria.
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Dangers of antibiotics are well known and recent research brings to light new dangers of commonly used medications. Five days of azithromycin results in 47 additional deaths from cardiovascular disease compared with amoxicillin and no antibiotic. One out of 2500 patients treated with a fluoroquinolone (ciprofloxacin, levofloxacin, and norfloxacin) suffer a retinal detachment. These antibiotics should be used only when there is a clear clinical need and with caution.
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In this study of patients imaged with CT angiography, finding of the presence of diagonal earlobe creases was independently and significantly associated with increased prevalence, extent, and severity of coronary artery disease.
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Two large, well-known, U.S. prospective cohort studies, the Nurses' Health Study and the Health Professionals Follow-up Study, evaluated both sugar-sweetened and diet (low-calorie, also called artificially sweetened) soda consumption over 20 years and found one or more daily servings to be associated with a significantly higher risk of stroke.
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Although current guidelines recommend delaying neuroprognostication during therapeutic hypothermia following resuscitation from cardiac arrest, this review of 55 consecutive patients so managed found that a "poor prognosis" designation was arrived at during the hypothermia period in most of them, including six patients who were eventually discharged with a favorable neurologic outlook.
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Timely recognition and treatment of myocardial infarction (MI) are crucial if we are to achieve optimal outcomes for our patients. Silent ischemia, or the absence of classical symptoms of ischemia, may delay the diagnosis.
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Infection is the second leading cause of death in hemodialysis patients, with mortality rates ranging from 12-36% in this vulnerable population.
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Two ICU patients experienced respiratory arrest while receiving polymyxin. Given the recent resurgence of use of this antibiotic and its close relative colistin to treat gram-negative infections resistant to newer agents, clinicians should be aware of this infrequent but long-known and potentially fatal adverse effect.
