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Inhaled bronchodilators are the cornerstone of managing acute airway obstruction, and their use in intubated, mechanically ventilated patients with asthma and COPD is a standard of care.
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Many of the recent advances in intensive care have been the product of large clinical trials. Over the years, randomized studies have demonstrated agents and modalities that impact survival of our sickest patients.
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Building on the results of previous pilot studies from their laboratory and a meta-analysis that showed a tendency toward improved mortality in critically-ill patients following selenium administration, Angstwurm and colleagues used a randomized, placebo-controlled multi-center trial to determine whether intravenous administration of selenium could improve outcomes in severe sepsis and septic shock.
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In the institution in which this study took place, an audit revealed that adherence to 9 ICU protocols ranged from 62% to 77%. The protocols focused on a variety of patient care needs including sedation/analgesia, DVT prophylaxis, enteral nutrition, insulin administration, skin care, stress ulcer prophylaxis, and ventilator weaning.
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IBS-Drug Treatment Pulled, CV Side Effects; Drug Combo Better for Migraine Treatment; Pergolide Off the Market, Heart Disease Risk; Hormone Treatment, Does Timing Matter?; FDA Actions
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In a group of smokers who were hospitalized with cardiac symptoms, a combination of 12 weeks of behavior modification counseling plus pharmacotherapy resulted in higher tobacco abstinence rates, lower re-hospitalization rates, and markedly reduced mortality rates compared with usual care over two years of follow-up.
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When compared to The Zone, Ornish, or LEARN diets, the very low carbohydrate diet (Atkins), showed that premenopausal, overweight, and obese women lost more weight and had the most beneficial metabolic effects at 12 months.
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The FDA has approved a new oral tyrosine kinase inhibitor with potent, reversible, selective dual inhibition of epidermal growth factor receptor (EGFR) and ErbB2 kinases.
