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An interesting therapeutic concept that has been put into clinical practice in the past several years is the use of nitric oxide donors for pulmonary hypertension.
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This report from the merlin-timi 36 investigators describes the effects of ranolazine on spontaneous arrhythmias in patients with acute coronary syndrome (ACS).
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Off-pump CABG avoids the complications of cardiopulmonary bypass (CPB), but is technically demanding.
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Cardiac death and perioperative myocardial infarctions occur in 2-20% (mean 6) of major noncardiac vascular surgery. Statins have been shown to have a protective effect, but the exact mechanism of this benefit is unclear.
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Lesley and colleagues analyzed a 5% national sample of Medicare inpatient, outpatient, and carrier files to examine the use of ICD therapy for both primary and secondary prevention of sudden cardiac death.
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Use of statins is associated with reduced rate of deterioration of lung function with aging, though the effect is reduced in those who continue to smoke.
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Exceptional attention has been paid to the recent publication of the COURAGE Trial (April 2007) regarding the efficacy of percutaneous coronary intervention (PCI) in stable coronary disease patients.
