Cardiology
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Coffin Nail for Omega-3 Fatty Acids?
A meta-analysis of 10 randomized, controlled trials of omega-3 fatty acids for the prevention of coronary heart disease and major vascular events showed no significant effect on fatal and non-fatal coronary heart disease or any major vascular event. These results do not support the use of omega-3 fatty acids supplements in patients with prior coronary heart disease.
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Methamphetamine-associated Pulmonary Hypertension and Cardiomyopathy Are Distinct Diseases
In a large study of methamphetamine users, female sex was associated with presence of pulmonary hypertension, whereas male sex, hypertension, and alcoholism were associated with cardiomyopathy. Both pulmonary hypertension and cardiomyopathy patients exhibited substantially increased mortality.
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Clinical Briefs
In this section: treating obstructive sleep apnea; influenza and myocardial infarction; and a promising Zika treatment.
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Tildrakizumab-asmn Injection (Ilumya)
Tildrakizumab-asmn is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
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Pre-existing Health Determines Quality of Life, Physical Symptoms After ICU Discharge
The authors of this nested cohort study within a randomized, controlled trial of ICU survivors requiring > 48 hours of mechanical ventilation found that pre-existing comorbidity was the main determinant of long-term health-related quality of life.
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Hospital Ice Machines Contaminated With Bacteria
Requiring staff to cleanse their hands with alcohol hand gel prior to using an ice machine and directing housekeeping personnel to perform more frequent machine cleaning may improve situation.
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Mefloquine: Still Effective and Still Safe for Malaria Chemoprophylaxis
Mefloquine is known as an effective agent for malaria chemoprophylaxis. However, concerns about serious adverse effects have limited its use. Now, a careful review of data suggests that fatal outcomes related to mefloquine prophylaxis are very rare.
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Routine Chest Radiographs After Ultrasound-guided Central Line Placement May Be Unnecessary
Catheter misplacement and pneumothorax after routine ultrasound-guided catheter placement are rare, and routine post-procedural chest radiographs may not be cost-effective.
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Real-time Tracking of Influenza-related ICU Use
Surrogate markers of influenza severity, specifically trends in ICU use, were collected and revealed differences from current influenza reporting.
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Management of Catheter-related Bloodstream Infections
Catheter-related bloodstream infections (CRBSIs) remain one of the more common nosocomial infections today, with an estimated 250,000 CRBSIs occurring in the United States annually, of which approximately 80,000 are associated with an ICU stay. The science behind current practices has reduced the CRBSI rate by 50% between 2008 and 2014. However, the rate of infection is far from zero, and rates remain significantly different between states, suggesting that there is room for improvement.