-
Migraine is associated with multiple disorders, including irritable bowel syndrome, restless legs syndrome, and non-alcoholic fatty liver disease. Understanding how these disparate disorders link to migraine may lead to an increased understanding of the pathogenesis of this complex neurological condition.
-
The FDA has approved a mu-opioid receptor antagonist for the treatment of opioid-induced constipation (OIC). Naloxegol is a pegylated derivative of naloxone which acts on peripheral (e.g., gut) mu-receptors. It is marketed by AstraZeneca Pharmaceuticals as Movantik.
-
The trouble with the expense of treating hepatitis C virus (HCV) infections is that very few patients are acutely choking on it, since the largest pool of HCV patients are asymptomatic. Progression to end-stage liver disease, liver transplantation, and hepatocellular carcinoma the three most dreaded HCV consequences may seem distant to the asymptomatic or even modestly symptomatic patient.
-
Makani H, et al. Antihypertensive efficacy of angiotensin receptor blockers as monotherapy as evaluated by ambulatory blood pressure monitoring: A meta-analysis.
-
HIV may be acquired either vertically or horizontally. Vertical, or perinatal, transmission occurs when the virus is transmitted from mother to child in utero, during labor and delivery, or through breastfeeding. Horizontal transmission occurs when the virus is acquired behaviorally through the exchange of bodily fluids, typically through sexual contact or needle sharing.
-
-
Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of composite of death or nonfatal myocardial infarction but did increase the risk of major bleeding.
-
In a study of vulnerable elderly population at risk for disability, a structured, moderate-intensity physical activity program compared with a health education program significantly reduced major mobility disability.
-
Severe obstructive sleep apnea is associated with a 30% increase in risk of incident diabetes, controlling for multiple relevant confounders.
-
The FDA has approved the first free fatty acid form of omega-3. Previous formulations have been ethyl esters of omega-3-acids. The omega-3-carboxylic acid is a fish oil-derived mixture of 50-60% eicosapentaenoic acid (EPA) and 15-25% docosahexaenoic acid (DHA) along with other potentially active omega-3 fatty acids. It is marketed by AstraZeneca as Epanova.
