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Physician-assisted Dying: It’s ‘Perhaps the Central Question in Medical Ethics Today’
With physician-assisted dying currently legal in six states, hospitals are facing ethical questions on responding to requests and addressing conscientious objectors.
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First-ever Study of Genome Sequencing in the Common Forms of Epilepsy
In the first study with genome sequencing in the common forms of epilepsy, ultra-rare genetic mutations of known epilepsy genes were over-represented in the epilepsy population, compared to controls.
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EEG Reactivity Testing in Comatose Patients After Severe Brain Injury
Studies assessing EEG reactivity in comatose patients after severe brain injuries are highly variable and almost never provide replicable definitions for presence or absence of EEG reactivity, even though it is used increasingly as a prognostic measure.
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Guillain-Barré Syndrome and Hepatitis E
Hepatitis E is the most common form of viral hepatitis worldwide and often is asymptomatic. But it is commonly associated with Guillain-Barré syndrome and Guillain-Barré variants.
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Differences in Disease Duration in LBD May Be Related to Pathologic Burden
This observational study of 807 autopsy-confirmed cases of Lewy body disease used Braak neurofibrillary tangle staging, frequency of neuritic plaques, and Lewy body staging to demonstrate that those individuals who had diffuse LBD had a shorter disease duration than those with transitional LBD localized to the limbic region.
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Ocrelizumab for Multiple Sclerosis
A Phase III trial of ocrelizumab in primary-progressive multiple sclerosis and two Phase III trials of ocrelizumab in relapsing-remitting multiple sclerosis have demonstrated efficacy with treatment.
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New Tools for the Diagnosis of CJD
Cerebrospinal fluid analysis using second-generation, real-time, quaking-induced conversion has a high sensitivity and specificity for the diagnosis of Creutzfeldt-Jakob disease.
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Fatal Infection Resistant to All Antibiotics
Last August a female patient in an acute care hospital in Reno, NV, died of carbapenem-resistant Enterobacteriaceae that was resistant to 26 antibiotics. The pathogen was Klebsiella pneumoniae that was isolated from a wound specimen. Of note, the patient had recently been hospitalized in India, and the specific enzyme conferring pan resistance was first discovered in that country: New Delhi metallo-beta-lactamase.
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MRSA Screening Has Collateral Benefits
Lead author Martin E. Evans, MD, an infectious disease physician at the University of Kentucky in Lexington, reports that infection rates fell 80% percent in non-ICUs, and 81% percent in spinal cord injury units.
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Wanted: The Next Generation of Infection Preventionists
A national survey of 4,078 infection preventionists shows that the field is approaching a demographic cliff, as 41.6% of respondents were age 56 years or older.