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Even as multicenter studies with central IRB reviews gain traction, some IRBs are still hesitant to join in. However, coordinating a multisite study among several IRBs within the same university system can be a time and paperwork hassle for both principal investigators and IRBs and could make previously reluctant IRBs consider a new central reliance agreement.
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Evaluating research risk requires understanding a variety of potential harms and their nuanced impact. IRBs might find it useful to have a matrix to help explore each potential harm.
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As IRB offices gear up for a busy academic research year, its a good idea to dust off IRB templates, checklists, and other tools to revise, improve, and adapt to technology and other changes.
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For many years, the IRB office at Childrens Hospital Los Angeles (CHLA) followed a process that was standard at most institutions: long, regularly scheduled meetings organized to review an ever-increasing number of protocols.
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In this large prospective study of trauma patients, the most important factor associated with post-traumatic seizures was the presence of alcohol intoxication.
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A large, multicenter clinical trial that compared protocol-based care to usual care for patients presenting to emergency departments with early sepsis and septic shock found no differences in clinical outcomes. However, early recognition and therapy was beneficial and should be the standard of care.
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Compared to manual surveillance methods, an electronic surveillance tool for catheter-associated urinary tract infections had a high negative predictive value but a low positive predictive value.
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Patients on mechanical ventilation who were managed with both conservative fluid administration and aggressive diuresis weaned faster, had significantly more ventilator-free days, and experienced reduced incidences of both ventilator-associated complications and ventilator-associated pneumonia.
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During my final year of interventional cardiology training, a woman in her 60s was brought emergently to the cath lab in cardiogenic shock, with diffuse ST-segment elevations.
