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The rate of invasive methicillin-resistant Staphylococcus aureus (MRSA) infection in dialysis patients is higher than for any other known patient population and is 100 times higher than for the general population, the Centers for Disease Control and Prevention reports.
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Often, the emergency department (ED) evaluation of a painful knee is a quick x-ray followed by discharge with the limb placed a knee immobilizer, the patient walking with crutches, a prescription for analgesics, and a referral to see an orthopedist next week.
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The prognosis for CML blast crises remains poor even with imatinib therapy. Dasatinib is an oral multi-targeted tyrosine kinase inhibitor of BCR/ABL and Src with clinical activity against imatinib-resistant CML.
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Dose-dense CHOP chemotherapy was compared with standard CHOP for patients with aggressive non-Hodgkin lymphoma. For young patients with low-intermediate risk disease there was improvement in response rate and survival.
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Torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, has been in development by Pfizer for nearly 15 years.
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There is emerging evidence that maintenance chemotherapy is of value for ovarian cancer patients after surgery and remission-induction chemotherapy.
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A meta-analysis of existing data on the primary management of operable breast cancer in elderly women demonstrates that when the approach is hormonal (tamoxifen) rather than surgery, local recurrence is higher. Overall survival, however, was not different.
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In a series of 16 patients with CML blast crisis, treatment mitoxantrone, etoposide, and imatinib on four different schedules was studied in a phase I/II trial.