Critical Care Alert – May 1, 2020
May 1, 2020
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Vitamin C, Thiamine, and Hydrocortisone for Septic Shock
The combination of vitamin C, thiamine, and hydrocortisone did not improve outcomes compared with hydrocortisone alone in patients with septic shock.
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Impact of Intensive Care Unit Personnel Decisions and Staffing on Patient Outcomes
Nurses with relatively high autonomy, alongside a dedicated intensive care unit (ICU) clinical pharmacist and 24/7 intensivist coverage, were associated with the lowest hospital mortality, shortest ICU lengths of stay, and shortest mechanical ventilator durations compared to other staffing models.
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Maximal Lung Recruitment Strategy Does Not Reduce Ventilator-Free Days in the Setting of Acute Respiratory Distress Syndrome
In this randomized trial, daily maximal recruitment trials failed to reduce ventilator-free days in the setting of acute respiratory distress syndrome, but increased the risk of cardiovascular adverse effects.
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Antibiotic Therapy to Reduce the Incidence of Ventilator-Associated Pneumonia After Cardiac Arrest
In this prospective, randomized trial, intravenous amoxicillin-clavulanate (dosed three times daily and given for two days) administered to patients admitted with out-of-hospital cardiac arrest due to a shockable rhythm reduced the incidence of early ventilator-associated pneumonia.