OB/GYN Clinical Alert – December 1, 2010
December 1, 2010
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Incidence and Mortality Data from the Women's Health Initiative
The authors investigated invasive breast cancer incidence and mortality after a total follow-up of 11 years among the 16,608 postmenopausal women aged 50-79 years with no prior hysterectomy who were randomized to combined oral conjugated equine estrogens (0.625 mg/day) plus medroxyprogesterone acetate (2.5 mg/day) or placebo in the Women's Health Initiative (WHI) HRT study. In the initial reports from the WHI HRT study, breast cancer incidence was increased (hazard rate [HR], 1.26; 95% confidence interval [CI], 1.00-1.59). -
Prenatal Care: Is Earlier Better?
For many years we have been pushing the concept that the earlier that prenatal care is initiated, the better will be the outcome. Since there are certainly data proving that late enrollment makes for worse outcomes, this "the-earlier-the-better" mantra has almost attained bumper sticker status. -
Misoprostol Is Not for Everyone
This trial was a randomized double-blind control trial of 89 women undergoing consecutive removal and replacement of a levonorgestrel-releasing intrauterine device (LNG-IUD). Of note, this study was part of a larger multicenter trial evaluating the bleeding profile and safety with repeat use of a LNG-IUD in women who had used their first device for close to 5 years. -
Amniotic Sheets — A Sheet Is Not a Band
It seems that at least twice a week we either inadvertently find, or have a pregnant patient referred with a band-like structure that runs north-to-south between the uterine walls. In a non-pregnant uterus this would be called a synechium, but the most common label assigned to this finding in pregnancy is a "sheet." -
Early Detection and Treatment of Ovarian Cancer Improves Outcome: Right?
Early Detection and Treatment of Ovarian Cancer Improves Outcome: Right? -
Treating Sexual Dysfunction Related to Antidepressant Use
A study group of 98 patients were enrolled through seven centers to evaluate the efficacy of sildenafil in the treatment of sexual dysfunction associated with the use of selective and nonselective serotonin reuptake inhibitors (SRIs). -
Pharmacology Watch: Tiotropium for Uncontrolled Asthma
In this issue: Tiotropium for uncontrolled asthma, sibutramine pulled from market, incidence and mortality data from WHI, FDA Actions. -
Clinical Briefs in Primary Care supplement