OB/GYN Clinical Alert – July 1, 2010
July 1, 2010
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Antibiotic Use during Pregnancy and Risk of Birth Defects
The purpose of this study was to estimate the association between antibacterial medications and selected birth defects. -
Hyperglycemia and Adverse Pregnancy Outcome
This spring a consensus opinion appears in the journal Diabetes Care, which represented a summary of deliberations of the International Association of Diabetes in Pregnancy Study Groups (IADPSG), a collaboration of 225 experts in the field from 40 countries, who gathered in Pasadena, CA, in June 2008. Since the current screening protocol for gestational diabetes (GDM) is about 40 years old, the group's goal was to make recommendations based on the best up-to-date information. -
Hormone Therapy and Risk of Lung Cancer
Lung cancer is the leading cause of cancer-related mortality among women. To investigate the potential role of hormone replacement therapy (HRT) in lung cancer development, the authors evaluated a prospective cohort of 36,588 peri- and postmenopausal women aged 50-76 years from Washington State recruited in 2000-2002 as part of the Vitamins and Lifestyle (VITAL) Study. -
Adding Another Standard to Platinum-sensitive Recurrent Ovarian Cancer
To assess the efficacy and toxicity of combination pegylated liposomal doxorubicin (PLD) and carboplatin against industry-standard paclitaxel and carboplatin, patients with histologically proven ovarian cancer with recurrence more than 6 months after first- or second-line platinum- and taxane-based therapies were randomly assigned by stratified blocks to CD (carboplatin area under the curve [AUC] 5 plus PLD 30 mg/m2) every 4 weeks or CP (carboplatin AUC 5 plus paclitaxel 175 mg/m2) every 3 weeks for at least 6 cycles. -
News Brief: Check Your Approach in Taking Sexual History
Learn to be more specific in your sexual health history taking. Results of a new study from the Kinsey Institute for Research in Sex, Gender and Reproduction at Indiana University in Bloomington indicate that no uniform consensus exists when the term "had sex" is used. -
Pharmacology Wathc: PPIs, Clostridium difficile, and Bone Fractures
In this issue: New reports about proton pump inhibitors and the effects of gastric suppression, pioglitazone vs vitamin E for non-alcoholic steatohepatitis, metformin and vitamin B12 deficiency, and FDA Actions. -
Clinical Briefs in Primary Care supplement