OB/GYN Clinical Alert – June 1, 2005
June 1, 2005
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Is Long-Term Alendronate Treatment a Problem?
Odvina and colleagues report 9 patients (8 women and 1 man) who sustained spontaneous, atraumatic, nonspinal fractures while on alendronate treatment. One patient also had a lumbar spinal fracture, but almost all of the fractures occurred in skeletal sites rich in cortical bone. In addition, 6 of the 9 patients displayed either delayed or absent fracture healing. -
Oral Contraceptives and Stroke Risk
This meta-analysis of 36 articles culled from a pool of 779 publications included 20 different populations. Four were cohort studies and 16 were case-controlled. Among the cohort studies, the pooled odds ratio (OR) showed no increased risk of stroke with oral contraceptive use. -
Proteomic Profiling in Ovarian Cancer: Is it Plausible?
Reproducibility of complex proteomic signatures in detecting early stage ovarian cancer has proven to be a significant challenge in the field of biomarker discovery. Although early reports of proteomic profiling demonstrated near 100% sensitivity and specificity in discriminating ovarian cancer from non-cancer, the ability to reproduce these results across datasets has been difficult. -
Alendronate vs Risedronate
Rosen and colleagues reported the results of a 1-year, multicenter, randomized, clinical trial comparing the once-a-week administration of alendronate and risedronate to postmenopausal women with osteoporosis (the FACT study-Fosamax Actonel Comparison Trial). The 1053 women were treated with either 70 mg alendronate or 35 mg risedronate weekly, taken with a full glass of water after fasting, and in the upright position after awakening in the morning. -
Exercise and Stress Management Training on Markers of Cardiovascular Risk in Patients with Ischemic Heart Disease
Blumenthal and colleagues point out in the introduction that psychological factors are recognized to play a significant and independent role in the development of ischemic heart disease and its complications, but it is not clear if psychological or behavioral interventions will reverse established cardiac conditions. They undertook the present study to test the hypothesis that stress reduction would lead to better cardiovascular health in individuals with established ischemic heart disease. -
Special Feature: Primary Spontaneous Intracerebral Hemorrhage
The well-known mantra of primary ovarian cancer management is surgery. The procedure has modified little in the last 30 years as the goal in advanced cases has been cytoreduction and, in seemingly early cases, it has been accurate staging. -
Pharmacology Watch: Is Nesiritide Associated with a Higher Death Rate?
Stopping Aspirin Before Surgery; The Sponge Returns; Preventing Metabolic Syndrome; FDA Actions -
Clinical Briefs in Primary Care supplement