OB/GYN Clinical Alert – May 1, 2003

May 1, 2003

• The WHI and Quality of Life

  An analysis of the effect of daily estrogen-progestin administration to postmenopausal women was summarized on the Internet site of the New England Journal of Medicine on March 17. The authors' message suggests that postmenopausal hormone therapy should be used only as brief treatment for severe menopausal symptoms.

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• A Phase II Study of Docetaxel in Paclitaxel-Resistant Ovarian and Peritoneal Carcinoma: A Gynecologic Oncology Group Study

  Docetaxel is active in paclitaxel-resistant ovarian and peritoneal cancer, but, in view of significant hematologic toxicity, further study is warranted to ascertain its optimal dose and schedule.

  Read more about A Phase II Study of Docetaxel in Paclitaxel-Resistant Ovarian and Peritoneal Carcinoma: A Gynecologic Oncology Group Study - OB/GYN Clinical Alert – May 1, 2003

• Sacrospinous Cervicocolpopexy with Uterine Preservation for Elderly Women

  Sacrospinous cervicocolpopexy with uterine conservation in elderly women with prolapse can be used to avoid the morbidity of hysterectomy.

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• Oral Contraceptives and Hypertension

  The use of oral contraceptives in women with hypertension produced higher blood pressures and poor control of blood pressure.

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• Women’s Perceptions About Treatment Decision-Making for Ovarian Cancer

  Women with advanced epithelial ovarian cancer did not describe the treatment decision-making process as shared; rather, they described an interaction that was directed by their physician.

  Read more about Women’s Perceptions About Treatment Decision-Making for Ovarian Cancer - OB/GYN Clinical Alert – May 1, 2003

• Special Feature: Alternatives to Menopausal Hormone Therapy

  One of the benefits that has come from the release of the data from the Prempro® arm of the Womens Health Initiative (WHI) on July 9, 2002, has been a re-evaluation of the pros and cons of menopausal hormonal therapy. In undertaking this appraisal, one inevitably asks what are rational alternatives to hormone use.

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• Pharmacology Watch: Counterfeit Procrit Uncovered by FDA Surveillance

  Counterfeit Procrit Uncovered by FDA Surveillance; Pharmaceutical Marketing Campaigns in Full Swing; Ambulatory Antibiotic Reduction: Take the Good with the Bad; Nefazodone Under Attack Once Again; Lindane Receives Black Box Warning; Aspirin Could Help Reduce Colorectal Adenomas;

  Read more about Pharmacology Watch: Counterfeit Procrit Uncovered by FDA Surveillance - OB/GYN Clinical Alert – May 1, 2003

• Clinical Briefs in Primary Care Supplement

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