OB/GYN Clinical Alert – March 1, 2003

March 1, 2003

• The Prevalence of Interstitial Cystitis in Gynecologic Patients with Pelvic Pain, as Detected by Intravesical Potassium Sensitivity

  The potassium sensitivity test (PST) was administered to 244 patients with pelvic pain and 47 control patients by enrolling gynecologists at 4 separate facilities. Previous work by these physicians had shown that the test appears to identify the presence of interstitial cystitis (IC) by detecting abnormal permeability of the bladder epithelium.

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• Effects of Oral Androstenedione Administration on Serum Testosterone and Estradiol Levels in Postmenopausal Women

  Synopsis: Acute oral administration of 50 mg and 100 mg of androstenedione to postmenopausal women increases serum testosterone and estrone but not estradiol.

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• VBAC Revisited Again

  Synopsis: Postpartum fever after cesarean delivery is associated with an increased risk of uterine rupture during a subsequent trial of labor.

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• Anti-HER2 Antibody, Trastuzumab in Patients with Recurrent or Refractory Ovarian or Primary Peritoneal Carcinoma with Overexpression of HER2

  Synopsis: The clinical value of single-agent trastuzumab in recurrent ovarian cancer is limited by the low frequency of HER2 overexpression and low rate of objective response among patients with HER2 overexpression.

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• Special Feature: Measuring Testosterone

  There are 2 important potential uses for the measurement of testosterone levels: 1) to monitor the dosage of testosterone supplementation; and 2) to diagnose hyperandrogenism, whatever the cause. Unfortunately, the measurement of testosterone is particularly difficult in women because of the low circulating levels.

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• Pharmacology Watch: Smallpox Vaccination Guidelines Published by CDC

  Smallpox Vaccination Guidelines Published by CDC; Nurses: Delay Vaccination Program; Viagra Effective for Depression Treatment; Finisteride/Doxazosin no Better than Placebo for Urinary Obstruction; Serevent Receives Dear Doctor Letter

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• Clinical Briefs in Primary Care Supplement

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