Neurology Alert – February 1, 2019
February 1, 2019
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Continuous EEG Monitoring in Critically Ill Patients Is Associated With Reduced Hospital Mortality
In this retrospective cross-sectional study involving more than 7 million critically ill adult patients from the National Inpatient Sample database, researchers showed that the use of continuous electroencephalography is associated with lower in-hospital mortality.
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Rituximab for CIDP Associated With Systemic Immune Disorders
Rituximab has been used “off label” for the treatment of primary chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with variable reports of success. These authors reported a high rate of response in patients who developed CIDP in the setting of other systemic immune-mediated disorders.
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Amyloid-ß Pathology Induced by Contaminated Cadaver-Derived Growth Hormone
Cadaveric pituitary-derived growth hormone that previously was known to transmit Creutzfeldt-Jakob disease (CJD) also contains ß-amyloid. Growth hormone vials from cases associated with amyloid plaques in CJD patients cause amyloid plaque formation and cerebral amyloid angiopathy when injected intracranially into mice.
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Predicting the Risk of Mild Cognitive Impairment Using Imaging Biomarkers
In this population-based study, researchers used imaging biomarkers of amyloid and neuronal injury to estimate an absolute risk of mild cognitive impairment in the elderly.
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Thinking Outside of the ‘Alpha-Synuclein Box’: A Critical Role of Tau in Lewy Body Disorders
Neocortical tau pathology was associated with worse antemortem cognition in this large study of Parkinson’s disease dementia and dementia with Lewy bodies. Regional brain variations correlated with specific cognitive domains.