Neurology Alert – June 1, 2003
June 1, 2003
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Therapeutic Vaccine for ALS?
This article reports the novel observation that therapeutic vaccination with Copaxone (glatiramer acetate, Cop-1), protects motor neurons against acute and chronic neurodegenerative conditions. -
Pallidotomy vs Medical Therapy for Parkinson’s Disease
Surgical treatment for Parkinsons disease has become increasingly used as a modality of treatment. Nevertheless, the efficacy and its long-term outcomes as compared to medical therapy are not well established. -
Machado-Joseph, Muscle Cramps, and Mexiletine
Spinocerebellar ataxia type 3, Machado-Joseph disease (MJD), is an adult onset, autosomal-dominant disorder often presenting as a combination of upper and lower motor neuron signs, including facial and tongue fasciculations, resembling amyotrophic lateral sclerosis (ALS). -
Rapid Parkinsonism Follows 20% of Cirrhosis
The neurological manifestations of chronic cirrhosis and hepatic failure are protean. Myoclonus (often negative), chorea, and dystonia may occur in these patients, often accompanied by pyramidal dysfunction and dementia. -
Late Breakers
A new oral direct thrombin inhibitorximelagatran (Exanata; Astra-Zeneca)steals the stage at this years American College of Cardiology 52nd Scientific Session in Chicago. -
Hydroxyurea and HbF in Sickle Cell Disease
In patients with sickle cell anemia (SCA), increasing the levels of fetal hemoglobin (HbF) decreases sickle cell hemoglobin polymerization and erythrocyte sickling. -
Prothrombotic Factors are Highly Associated with Cerebral Venous Sinus Thrombosis
Cerebral venous thrombosis (CVT) is a stroke syndrome characterized by headache, seizures, and hemorrhagic infarction. -
Immunosuppression, IVIG, and Diabetic Lumbosacral Plexopathy
Intravenous immunoglobulin (IVIG) is an expensive but powerful and useful therapeutic tool in the neurologists armamentarium. Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, Lambert-Eaton myasthenic syndrome, and dermatomyositis have all been shown, in controlled clinical trials, to benefit from IVIG. -
Pharmacology Watch: Pneumococcal Vaccine Ineffective at CAP Prevention
Pneumococcal vaccine protects older adults from developing pneumococcal bacteremia but does not prevent community-acquired pneumonia (CAP), according to a new study from Group Health Cooperative in Seattle.