– September 1, 2004
September 1, 2004
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The Long Look: 10-Year Follow-Up of Adjuvant Colon Trial NSABP C-01
The 10-year disease-free and overall survival rate is presented from a trial of adjuvant therapy (chemo-, or immunotherapy) for Dukes B and C colon cancer conducted by the National Surgical Adjuvant Breast and Bowel cooperative group. The disease-free and overall survival advantage for the chemotherapy arm, apparent at 5 years, was no longer evident by 10 years. -
Doxorubicin + Cisplatin vs Doxorubicin + 24-h Paclitaxel + Filgrastim in Endometrial Carcinoma
Doxorubicin and 24-h paclitaxel plus filgrastim was not superior to doxorubicin and cisplatin in terms of response, PFS or survival in advanced endometrial cancer. -
Breast Feeding and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers
The influence of breast feeding upon breast cancer development was examined in women who carry deleterious mutations of the BRCA gene. They found that one or more years of breast feeding in women with deleterious BRCA1 gene mutations was associated with a reduction in breast cancer risk of 45%, an effect that is much greater than that observed in the general population. -
Rethinking Combination Chemotherapy: Concomitant vs Sequential Drug Treatment for Breast Cancer
Epirubicin and paclitaxel were administered either in combination or sequentially to 202 patients with metastatic breast cancer to demonstrate noninferiority of the sequential approach. Response rates and survival were comparable in the 2 groups, but toxicity was greater (neutropenia and neuropathy) in those that received the drugs sequentially rather than in combination. -
Frequency of Symptoms of Ovarian Cancer in Women Presenting to Primary Care Clinics
Symptoms that are more severe or frequent than expected and of recent onset warrant further diagnostic investigation because they are more likely to be associated with both benign and malignant ovarian masses. -
Pharmacology Watch: New Clinical Guidelines on Cholesterol Management
Hypothyroidism and Pregnancy; Anti-Depressants and the Risk of Suicide; FDA Actions; Brief Notes. -
Clinical Briefs in Primary Care supplement