– June 1, 2008
June 1, 2008
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Adjuvant Chemotherapy after Successful Gastric Cancer Surgery: Yes, Maybe, or No
In a Phase III randomized trial of adjuvant chemotherapy using the platinum-based PELF (platinum, etoposide, leucovorin, and fluorouracil) regimen after potentially curative surgery for gastric cancer, no significant improvement in disease-free or overall survival was observed. The findings are discussed in the context of other trials and highlight the uncertainty surrounding the appropriate approach for the treatment of patients in this setting. -
LHRH Treatment or Orchiectomy? The Influence of Medicare Reimbursement
Orchiectomy rates have increased and LHRH prescriptions have decreased over the past 5 years. Could this be related to Medicare reimbursement? -
Molecular Tests Discriminate Prognosis in Normal Karyotype AML
Mutations in several genes may refine prognosis in normal karyotype AML. -
What To Do with the Incidental Finding of Lobular Neoplasia?
The management of an isolated core needle breast biopsy reading of lobular neoplasia (LN) is controversial. Although this finding is associated with an increased risk for cancer, the current belief is that it, itself, is not a pre-malignant lesion. -
Pharmacology Watch
Pioglitazone and heart disease; ARBs manufacturers spend millions to show the non-inferiority of their products compared to less expensive, generic ACE inhibitors; some athletes turn to growth hormone because it is difficult to detect; FDA Actions -
Clinical Briefs in Primary Care supplement