Internal Medicine Alert – March 15, 2019
March 15, 2019
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Apolipoprotein E and CSF Levels in Men and Women With Alzheimer’s Disease
Apolipoprotein E epsilon 4 (APOE4) genotype, the stronger genetic risk factor for late-onset Alzheimer’s disease, negatively affects cerebrospinal levels of tau protein in a sex-dependent manner, whereby the effect of APOE4 is stronger in women than men.
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Clinical Outcomes After Oral Anticoagulant-Associated Intracerebral Hematoma
In this meta-analysis of multiple observational studies, clinical outcomes after oral anticoagulant-associated intracerebral hematoma were similar for those associated with vitamin K antagonists or the new class of direct oral anticoagulants.
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Combination Drug Therapy for Hypertension
A large regional database study from Italy revealed that initial combination therapy for newly diagnosed hypertension results in fewer major adverse cardiovascular events at one year compared to monotherapy.
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Homeless Population Requires Hepatitis A Vaccination
A multistate outbreak of hepatitis A virus (HAV) infection in the homeless and/or drug-using population has prompted the United States Advisory Committee on Immunization Practices to add “homelessness” as an indication for HAV vaccination. This is in addition to existing indications for HAV vaccination of men who have sex with men and illicit drug users (with the exception of marijuana use).
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Caplacizumab-yhdp for Injection (Cablivi)
Caplacizumab-yhdp is indicated for the treatment of acquired thrombotic thrombocytopenic purpura in combination with plasma exchange and immunosuppressive therapy.
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Are the Changes Acute?
Imagine the ECG in the figure was obtained from a previously healthy, middle-aged man who presented to an ambulatory clinic for “indigestion.” How might one interpret the ECG?