Internal Medicine Alert – February 15, 2014
February 15, 2014
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Effect of Vitamin E and Memantine in Alzheimer's Disease
Among patients with mild-to-moderate Alzheimer's disease, 2000 IU/d of vitamin E resulted in a slower functional decline and a decrease in the caregiver burden. -
Spironolactone for Heart Failure
The authors concluded that in a diverse, community-based population with new systolic heart failure, spironolactone did not reduce death or hospitalization, but did increase the incidence of hyperkalemia. -
New Oral Anticoagulants Poised to Alter Approach to AF
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Vitamin D and Pain
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Dapagliflozin Tablets (Farxiga)
A second sodium-glucose cotransporter 2 (sglt2) inhibitor has been approved for the treatment of adults with type 2 diabetes mellitus. These agents increase glucose secretion by inhibiting reabsorption in the kidney. Renal glucose threshold can be lowered to 70-90 mg/dL from a norm of 240 mg/dL in patients with diabetes. Dapagliflozin follows canagliflozin as the second SGLT2 approved and is marketed by Bristol-Myers Squibb and AstraZeneca as Farxiga. -
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