Infectious Disease Alert – April 1, 2007
April 1, 2007
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Posaconazole for Azole-Refractory Candidiasis in Patients with HIV Infection
This paper reports the results of an important multinational trial which evaluated the use of two different regimens of posaconazole in the treatment of OPC or EC which had been refractory to either fluconazole or itraconazole. -
Azithromycin for Traveler's Diarrhea in Thailand
U.S. military personnel in Thailand presenting with the acute onset of diarrhea were randomized to treatment with one of 3 regimens: a single 1 g dose of azithromycin, 500 mg of azithromycin daily for 3 days, or 500 mg levofloxacin daily for 3 days. -
Advisory Committee on Immunization Practices Issues Guidelines for Gardasil, HPV Vaccine
The Advisory Committee on Immunization Practices (ACIP) has finally published its recommendations for the use of Gardasil, the quadrivalent human papillomavirus vaccine that has recently become available. -
RotaTeq Safety
Rotashield, a vaccine protective against rotavirus infection was withdrawn from the U.S. market because of an apparent excess risk of intussusception. The recent introduction of a new vaccine, RotaTeq, has inevitably led to concerns about an increased incidence of this complication in children receiving this vaccine, as well. -
Metabolic Syndrome in HIV-Infected Patients
This important study compared an outpatient cohort of 471 HIV-infected outpatients living in the Midwest to data files from the NHANES cohort of HIV-negative subjects matched by age, sex, race, and tobacco use. -
Flu Then Flu Now: New Estimates on Pandemic Influenza Deaths
It has become in vogue to plan for influenza pandemics. What is not clear is what would be excess mortality in such a pandemic. -
Varicella Vaccine, Breakthrough Varicella, and Duration of Immunity
From community-based active surveillance data in Antelope Valley, California, (northeast of Los Angeles) from 1995-2004, 9.5% (1,080 subjects) of all 11,356 subjects with varicella had onset of rash > 42 days after varicella vaccination, which defines breakthrough varicella. The diagnosis was confirmed by physician evaluation or laboratory test in 770 subjects (71.3%). -
Pneumococcal Vaccine and Antimicrobial Resistance in Children
Streptococcus pneumoniae isolates were collected from children (<14 yrs of age) with community-acquired respiratory tract infections (acute otitis media, community-acquired pneumonia, acute maxillary sinusitis, or acute rhinosinusitis) from 2000-2004 in 112 centers in 38 states. -
Updates By Carol A. Kemper, MD, FACP
The San Francisco Bay area is now home to one of the largest Asian Indian populations in the United States, especially in Silicon Valley, where it is estimated that 40% of the computer programmers are Asian Indian. -
Pharmacology Watch: Which Inhaler Combination is Best for COPD Treatment?
First Antihypertensive Drug Approved in Last 10 Years: Aliskiren; Alternate Treatment for Osteoporosis; Roche's Oseltamivir: Scrutiny, Bird Flu, and New Drug Applications; FDA Actions -
Clinical Briefs in Primary Care supplement