Infectious Disease Alert – May 1, 2006
May 1, 2006
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Mitochondrial Toxicity Associated with Linezolid
Linezolid is an oxazolidinone antibiotic which has proven to be very useful in the treatment of Gram positive bacterial infections, including methicillin-resistant S. aureus (MRSA). -
When Mononucleosis Does Not Get Better
When Primary Ebstein-Barr Infection occurs in early childhood, it is usually asymptomatic. Infection later, during adolescence or in adulthood, is associated with a classic syndrome that we term infectious mononucleosis (IM), mono in the vernacular. -
Tenofovir-Associated Nephrotoxicity
This paper reports on 5 HIV-infected patients receiving TDF-containing antiretroviral (ARV) therapy who developed ARF. One patient had associated Fanconi syndrome/renal tubular acidosis (RTA). -
Linezolid for Gram-Positive Infections of Neutropenic Patients
This study ran from November 2000 to May 2002, recruited 611 patients from 58 centers predominantly from Europe, and set out to compare the efficacy and safety of these drugs for treating febrile, neutropenic patients with cancer and either proven or suspected infection due to Gram-positive bacteria in a prospective, blinded randomized controlled trial. -
Tropical and Geographic Medicine
Thirty-three of the more than 3000 lost boys of Sudan (mean age, 25 years) in the United States were evaluated. All but 6 reported chronic abdominal pain. Ten (48%) of 21 had Schistosoma mansoni and one had S. haematobium infection, while 5 (20%) of 25 were HBsAg carriers and 3 (12%) of 25 had chronic hepatitis due to HBV. -
Updates By Carol A. Kemper
The California Influenza Strain (A/California/07/2004 [H3N2]), first isolated in our own backyard in Santa Clara County, included in the 2005-2006 trivalent influenza vaccine, has been given the boot! -
Pharmacology Watch: Reversal of Atherosclerosis Via Intensive Statin Therapy
Alternative Therapy for Depression?; FDA Actions -
Clinical Briefs in Primary Care supplement