OB/GYN Clinical Alert – November 1, 2023

What Every OB/GYN Should Know About Cervical Cancer Prevention

This narrative review summarizes the steps of human papillomavirus (HPV)-mediated cervical carcinogenesis and uses this to explain current guidelines for HPV vaccination, cervical cancer screening, and management of abnormal results.

Implications of Reproductive Carrier Screening During Pregnancy

About 1 in 40 females who underwent reproductive carrier screening were found to be carriers for a disease that could cause maternal symptoms during pregnancy. Healthcare providers should be aware of the potential for complications among carriers of genetic conditions during pregnancy and the best practices for handling such cases.

Unscheduled Bleeding with the Contraceptive Implant: Is There Any Intervention that Works?

In this randomized controlled trial of 54 patients with frequent or prolonged bleeding or spotting on the etonogestrel contraceptive implant, curcumin (the active ingredient in turmeric) was no better than placebo at controlling the total number of bleeding or spotting days during the 30-day study period.

Multicomponent Intervention for Early Detection and Treatment of Postpartum Hemorrhage: E-MOTIVE

This international, parallel, cluster-randomized trial assigned 80 secondary-level hospitals in four African countries to evaluate a multicomponent intervention for early detection and treatment of postpartum hemorrhage (PPH) vs. usual care following a vaginal birth. The intervention group had 60% less severe PPH cases (> 1 L blood loss) than the usual care cohort.