OB/GYN Clinical Alert – December 1, 2025

Acetaminophen Use During Pregnancy and Neurodevelopmental Disorders

The synthesized evidence on prenatal acetaminophen exposure and neurodevelopmental outcomes highlights modest and inconsistent associations and emphasizes that causality remains unproven because of confounding and measurement biases. The authors conclude that, consistent with American College of Obstetricians and Gynecologists and Society for Maternal-Fetal Medicine guidance, acetaminophen remains appropriate in pregnancy when clinically indicated.

Spironolactone for the Treatment of Acne Vulgaris

In this meta-analysis of 563 patients from five randomized controlled trials, objective assessment of acne improvement was higher in the spironolactone group compared to the placebo group (odds ratio, 6.59; 95% confidence interval, 3.50-12.43).

Fertility-Sparing vs. Surgical Treatment for Stage I Endometrial Cancer

This retrospective cohort study using the National Cancer Database demonstrated similar overall survival between fertility-sparing treatment and hysterectomy for patients younger than 40 years of age with clinical stage 1, low-grade endometrial cancer (hazard ratio [HR], 1.00; 95% confidence interval [CI], 0.50-2.00) but an increased mortality risk for patients aged 40-49 years receiving fertility-sparing treatment (HR, 4.94; 95% CI, 1.89-12.91).

Long-Term Outcomes of Peripartum Cardiomyopathy

A large, prospective, observational study from Israel of peripartum cardiomyopathy has shown that, in general, outcomes are favorable, with high rates of left ventricular function recovery that remain stable and with no mortality but also that show high rates of cardiovascular comorbidities during long-term follow-up.