Internal Medicine Alert – November 15, 2023

Biomarker Profiles of Those Living to Age 100 Years

Among 1,224 participants who lived to their 100th birthday, there were higher levels of total cholesterol and iron, and lower levels of glucose, creatinine, uric acid, liver enzymes, and alkaline phosphatase compared with non-centenarians. These differences were seen as early as age 65 years.

The Hemodynamic Effects of an SGLT2 Inhibitor in Heart Failure with Preserved Ejection Fraction

The authors of a small, placebo-controlled study of 24 weeks of dapagliflozin therapy in patients with heart failure with preserved ejection fraction reported reductions in pulmonary capillary wedge pressure, which may explain the reductions in heart failure hospitalizations or cardiovascular death in larger randomized outcome trials.

Major Cardiovascular Event Risk Reduction with Pitavastatin in Patients Living with HIV

Among participants living with HIV who are at low-to-moderate risk for cardiovascular disease, those who received pitavastatin were 35% less likely to experience a major adverse cardiovascular event over a follow-up of approximately five years vs. those who received placebo.

Momelotinib Tablets (Ojjaara)

Momelotinib can be prescribed to treat intermediate- or high-risk myelofibrosis.

Aberrant Conduction?

How should one interpret the ECG in the figure? Is the rhythm most likely to be a re-entry supraventricular tachycardia with aberrant conduction?