Integrative Medicine Alert – November 1, 2023

Examining the Effect of Physical Activity and Depressive Symptoms in Adolescents

In a robust meta-analysis of 21 studies, physical activity interventions showed a significant short-term benefit for children and adolescents with depressive symptoms, particularly in those aged 13 years and older and in participants with a diagnosis of depression.

Can Internet Use Prevent Dementia?

In an ongoing longitudinal survey of a nationally representative sample of dementia-free adults age 50 to 64.9 years, regular internet users experienced approximately half the risk of dementia compared with non-regular users.

Searching for a Neuroprotective Agent in Celery Seed Oil

A Phase III double-blind, placebo-controlled, randomized, controlled trial suggests that early administration of DL-3-n-butylphthalide, when given adjunctively to thrombolysis or endovascular therapy, improves functional outcomes in patients with acute ischemic stroke. Statistically significant results of well-designed analyses are tantalizing, but confidence in the findings is tempered by a lack of generalizability, an unclear mechanism of action, and trial design irregularities.