Infectious Disease Alert – January 1, 2023

Statin Use with Daptomycin: Do We Finally Have a Definitive Answer?

A meta-analysis on published literature and a disproportionality analysis using Food and Drug Administration data found that statin use was associated with the occurrence of daptomycin-induced musculoskeletal adverse events. In most cases, statin use should be discontinued while patients are on daptomycin.

Salmonella Gastroenteritis — The Risk of a Rapid, Accurate Diagnosis

Availability of molecular testing panel results that were positive for Salmonella in children led to increased hospital admissions, increased subsequent microbiologic testing, and increased antibiotic use — all without benefit to patients.

Resistance of SARS-CoV-2 Variants to Monoclonal Antibodies

Prevalent SARS-CoV-2 variants are increasingly resistant to therapeutic and prophylactic monoclonal antibodies but remain susceptible to Paxlovid, remdesivir, and molnupiravir.

When More Is Not Better: Treatment of Prosthetic Valve Endocarditis Due to Staphylococci

Clear evidence of benefit from adjunctive administration a β-lactam and/or a glycopeptide in the treatment of prosthetic valve endocarditis due to staphylococci is lacking. Current guidelines need to be reassessed.

Vaccination Against Mpox: Does it Work? Is it Safe?

Vaccination, either subcutaneously or intradermally, with the non-replicating JYNNEOS vaccine is safe and effective.

The Dental Procedure-Infective Endocarditis Link Controversy Continues

Infective endocarditis was more common with dental surgery or tooth extractions in the preceding four weeks in high-risk patients. Researchers abrogated this risk with antibiotic prophylaxis before the procedure.

Infectious Disease Alert Updates

Loss of Monoclonal Therapy for COVID-19; Cost-Savings of Outpatient Antimicrobial Therapy