Clinical Cardiology Alert – January 1, 2023

January 1, 2023

• Mitral Transcatheter Edge-to-Edge Repair Gains Traction in Cardiogenic Shock Patients

  The authors of this large registry study examined transcatheter edge-to-edge repair in patients with cardiogenic shock and severe mitral regurgitation (MR). Successful repair was achievable in most patients and was associated with lower mortality rates and heart failure hospitalization at one year.

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• Triglyceride-Lowering Therapy and Cardiovascular Events

  Researchers studied pemafibrate vs. placebo in patients with type 2 diabetes, mild-to-moderate triglyceride elevations, and low levels of HDL and well-controlled LDL cholesterol. Despite a 31% reduction in triglyceride levels, there was no improvement in the risk of cardiovascular outcomes over a median follow-up of 3.4 years.

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• Is It Better to Up-Titrate Medications Faster in Acute Heart Failure Patients?

  Early intensive up-titration of guideline-recommended therapy in patients admitted for heart failure reduced 180-day readmission and all-cause mortality at the cost of more adverse events (but not serious or fatal ones).

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• Is Screening for Atrial Fibrillation Cost Effective?

  Self-screening for atrial fibrillation in elderly individuals could lead to lower stroke rates, prevent bleeding-related hospitalizations, and save money.

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• New Therapy for Resistant Hypertension

  Aprocitentan demonstrated efficacy for additional therapy beyond standard multidrug treatment in resistant hypertension.

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