Articles Tagged With: pregnancy
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Oral vs. IV Iron for the Treatment of Iron-Deficiency Anemia in Pregnant Women
Compared to oral iron, intravenous iron reduced maternal anemia at delivery (40% vs. 85%, P = 0.039), and rates of maternal hemoglobin < 10 g/dL were lower with intravenous iron compared to oral iron (10% vs. 54%, P = 0.029). Rates of mild to moderate adverse events were similar between the two groups, and no severe adverse reactions were noted with intravenous iron.
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The Pseudogestational Sac of Ectopic Pregnancy: Does it Really Matter?
In this retrospective cohort study of 1,236 women, the rate (2.2%) of ectopic pregnancy was rare among women with a fluid collection (or pseudosac) in the uterus. The size of the fluid collection was not predictive of ectopic pregnancy. The presence of an intrauterine fluid collection decreased the risk of ectopic pregnancy (adjusted relative risk, 0.09; 95% confidence interval, 0.05-0.19) after adjusting for age and the presence of bleeding.
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Is the Timing of Interval Postpartum Insertion of Intrauterine Device Associated with the Frequency of Complications?
Having an intrauterine device (IUD) inserted at four to eight weeks postpartum was associated with higher frequency of uterine perforation, but not higher frequency of expulsion, compared to IUD insertion at nine to 36 weeks postpartum. Overall, perforation and expulsion rates were low.
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The Effects of Maternal Cannabis Use During Pregnancy on the Neurobehavioral Development of Children at Ages 3-6 Years
This study examined associations between maternal cannabis use in pregnancy and neurobehavioral problems diagnosed in children between ages 3 and 6 years. Maternal cannabis use was associated with higher cortisol levels, as well as abnormal behaviors, including anxiety, aggression, and hyperactivity. Placental analyses for a subset of children indicate a potential mechanism for neurobehavioral disorders as the result of selective gene regulation.
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Pregnancy-Associated Mortality: The Contribution of Homicide
In this national study, there were 3.62 homicides per 100,000 live births among females who were pregnant or within one year postpartum from 2018 to 2019. This rate was slightly higher (16%) than the rate among nonpregnant and non-postpartum females of reproductive age. Homicide was found to be a leading cause of pregnancy-associated mortality.
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Intravenous Iron: Does This Therapy Increase the Risk of Infection?
In this systematic review and meta-analysis, among all populations, intravenous iron was associated with a slight increased risk of infection (relative risk, 1.17; 95% confidence interval, 1.04-1.31) compared to oral iron or no iron. However, there was no difference in mortality or length of hospital stay.
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Maternal Outcomes Following COVID-19 Infection in Vaccinated and Unvaccinated Pregnant Patients
Pregnant patients who received the COVID-19 vaccine had lower rates of severe or critical COVID-19 infections compared to pregnant unvaccinated patients.
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COVID-19 Vaccination, Pregnancy, Lactation, and Fertility
Vaccination rates are notably low among pregnant women. Clinicians should underscore the safety of vaccination and the risks of natural infection, particularly in pregnancy and in patients with underlying comorbidities.
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CDC Urges Pregnant Women to Get Vaccinated
Despite the risk of severe disease and death, about two-thirds of pregnant women are not receiving the COVID-19 vaccine.
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IRBs Often Reluctant to Approve Inclusion of Pregnant Participants in Research
Some IRB members cite uncertainty on whether inclusion of pregnant participants could affect the study’s scientific validity. Others acknowledge they rely on the common, default practice of excluding pregnant individuals without requiring justification. Guidance is needed for characterizing the risk level of research procedures in the context of pregnancy.