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San Francisco, CA, investigators found a significantly higher adherence among HIV-infected people who used pill boxes, and the same patients had increased viral suppression.
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On June 14, 2007, FDA approved a new formulation of fosamprenavir calcium (Lexiva).
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Over the last 15 years increased understand ing of the complicated process of HIV attachment and entry into host cells has developed. After initial binding of the virus' external envelope glycoprotein gp120 to CD4, the trimeric gp120 structure undergoes conformational change resulting in exposure of the third variable domain of gp120 (V3 loop) which then interacts with one of two coreceptors, CCR5 or CXCR4.
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The immune response to hiv exerts a selective pressure, just as do antiretroviral drugs. Cytotoxic T lymphocytes (CTL) that recognize HLA class I-restricted viral epitopes expressed on the surface of infected cells exert a pressure on these epitopes.
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Good news on the research front: Results from a major study indicate that treating genital herpes may help keep the AIDS virus under control in women with both infections and may reduce the spread of HIV as well.
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Highly active anti-retroviral therapy (HAART) has changed the nature of HIV dementia: the degree of cognitive impairment is milder, the course may improve as well as worsen, and traditional biomarkers such as CSF viral load or levels of monocyte chemotactic protein 1 (MCP-1) are less likely to be associated with dementia.
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According to a Government Accountability Office (GAO) report, U.S. citizens who appear to be eligible for Medicaid have faced significant access problems due to the new citizenship documentation rule, which was intended to weed out illegal aliens and not to punish U.S. citizens.
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While health care fee-for-service and capitation payment systems have been with us for many years, they have significant well-known flaws.
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Some members of Congress are backing legislation to fix what they say is a flawed Center for Medicare & Medicaid Services (CMS) Medicaid pharmacy reimbursement rule for generic drugs.
