-
C-reactive protein, an acute phase reactant, is shown to offer significant prognostic information for post nephrectomy patients with renal cell carcinoma. The value of this information will be enhanced if future studies indicate that patients with high levels are more likely to benefit from adjuvant therapy or if it turns out to be a sensitive marker of recurrent disease.
-
This multicenter trial evaluated the efficacy of combining alemtuzumab (Campath 1-H) to standard CHOP for peripheral T-cell lymphomas. Among 24 evaluable patients, the complete response rate was 17/24 (71%) using 8 cycles of CHOP plus 30 mg of Campath monthly.
-
The management of acute myelogenous leukemia in elderly patients has been challenging and there has developed a pervasive pessimism about the role of chemotherapy in management. Two recent reports may counter this with demonstration of a benefit for induction chemotherapy and, in selected cases, both efficacy and safety of stem cell transplantation using nonmyeloablative conditioning.
-
Are thiazolidinediones safe? New study shows Zometa reduces risk of hip fractures and improves survival; Merck HIV vaccine proven ineffective in clinical trials; no causal association found between exposure to mercury from thimerosal; and FDA approvals.
-
-
Outcomes for treatment of stroke with intravenous tissue plasminogen activator (tPA) were similar at community hospitals supported by telemedicine consultation with stroke experts compared to academic stroke centers.
-
Long-term monitoring is likely to detect atrial fibrillation in stroke patients with frequent atrial premature beats.
-
The US FDA Adverse Event Reporting System (AERS) was searched for reports of nephrolithiasis in HIV patients receiving atazanavir (ATV)-containing antiretroviral (ARV) regimens; 30 cases were identified.
-
Withdrawal of statin therapy in acute ischemic stroke may lead to increases in death and disability.
-
Carcinoma of unknown primary remains a management problem without an established approach demonstrated to prolong survival. In a phase II study, the combination of carboplatin, gemcitabine, and capecitabine was shown to be fairly well tolerated and, for certain subsets, effective in producing transient tumor regression.
