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Acute myeloid leukemia in the elderly has a poor prognosis using standard therapy. Lenalidomide is a thalidomide analogue with activity at low doses for low-risk MDS harboring a 5q-. Two institutions using different protocols evaluated high-dose lenalidomide induction (35-50 mg daily for 14-21 days, 14-30 days of rest) followed by lower dose maintenance (10 mg daily). Out of 33 patients, four patients had a complete response.
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Calcidiol (25(OH)D) levels were measured in a series of 160 Norwegian prostate cancer patients, and the results correlated with cancer-specific and all-cause mortality.
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In a randomized, phase 3 trial of two different schedules of chemotherapy and radiotherapy for patients with advanced larynx or hypopharynx cancer, no difference was observed in progression-free survival, overall survival, or the maintenance of laryngeal function.
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FDA warning on topical anesthetics; antipsychotics increase sudden cardiac death; the step up vs step down debate; treating pain, fatigue, mood, and sleep in fibromyalgia; FDA Actions.
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Use of the benzodiazepine-like hypnotics (z-hypnotics), zolpidem and zopiclone, is associated with an increased risk of crash, particularly in young people.
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Hypovitaminosis D was found to be highly prevalent in U.S. adults with CVD, particularly those with both coronary heart disease and heart failure.
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Vitamin B12 was effective in the treatment of recurrent aphthous stomatitis.
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The FDA has approved another selective serotonin and norepinephrine reuptake inhibitor for the management of fibromyalgia (FM).
