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The case is typical. the patient had a hip replacement eight years ago and, over the past six months, the hip has begun to hurt, walking is impaired, and the patient is becoming less mobile. The hip must be replaced. But is it infected?
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In January 2009, the publication of an updated vancomycin monitoring guideline1 gave clinicians a set of recommendations on: 1) timing of monitoring, 2) optimal trough concentration, 3) dosing to achieve optimal trough concentrations, 4) loading doses for complicated infections, 5) criteria for monitoring, and 6) frequency of monitoring.
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In this issue: Tamoxifen and CYP2D6 inhibitors, FDA Actions, and FDA
Warnings.
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HOPS is an ongoing prospective, observational cohort study of HIV-infected patients at 10 participating HIV clinics in the United States. A total of 2,699 patients with HIV RNA > 1,000 copies/uL were seen from 1999-2005. Demographic characteristics, clinical factors, and GPT use were correlated with all-cause mortality.
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In order to reduce the rate of catheter-related bloodstream infections (CRBSIs) in intensive care units, Northwestern Memorial Hospital implemented patient care bundles in all ICUs in August 2005.
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Neuropsychiatric side effects and sleep disturbances are among the more prominent and limiting features of efavirenz (EFV) therapy for HIV infection.
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The FDA has approved a single-dose formulation of Plan B, the emergency contraceptive previously available in a two-tablet dose.
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Two papers presented at the recent American Society of Clinical Oncology (ASCO) have brought to light to potential serious drug interaction between tamoxifen and several commonly used SSRI antidepressants.
