CME Questions

Which of the following statements is true about peptide-pulsed peripheral blood mononuclear cells plus IL-12 as a melanoma vaccine?

a. The toxicity of IL-12 makes this approach difficult for patients.

b. Extensive cell culture is required for the mononuclear cells needed for this vaccine.

c. Specific CD8+ T-cell responses were seen following vaccination.

d. Nonspecific immune activation was seen following vaccination.

Which of the following is (are) the tumor suppressor gene(s)?

a. DCC

b. p53

c. Both

d. Neither

What percentage of patients treated with bolus high-dose IL-2 can be expected to develop hypotension that requires pressor support?

a. < 1%

b. 5-10%

c. 20-30%

d. 40% or more

In the treatment of patients with osteolytic neoplastic disease, zoledronic acid, when compared to pamidronate, has been shown to:

a. be superior in preventing fractures.

b. require a much shorter injection (infusion) time.

c. be superior in preventing hypercalcemia.

d. All of the above

For patients with head and neck squamous cell carcinoma, which of the following statements about determination of serum sIL-2-R has been shown to be true?

a. It is a useful marker of tumor reappearance after chemotherapy.

b. It is a useful marker of disease recurrence.

c. It is a useful indicator of survival when obtained at the time of diagnosis.

d. All of the above