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The authors reviewed 12 articles representing 13 prospective studies searching for a link between vitamin B6 consumption or blood pyridoxal 5-phosphate (PLP, the main active coenzyme form of B6) and lower rates of colorectal cancer, finding a linear inverse relationship (relative risk 0.52) between blood PLP and colorectal cancer risk.

Vitamin B6 and Connections to Colorectal Cancer Risk