Teen Pregnancy Part 1: The First Trimester
September 1, 2020
AUTHORS
Lauren B. Querin, MD, MS, Medical Education Fellow, Clinical Instructor, Department of Emergency Medicine, University of North Carolina, Chapel Hill
Daniel Migliaccio, MD, Clinical Assistant Professor, Department of Emergency Medicine, University of North Carolina, Chapel Hill
PEER REVIEWER
Catherine Marco, MD, Professor, Department of Emergency Medicine, Wright State University, Dayton, OH
Acute care providers will frequently encounter an adolescent with a new diagnosis of pregnancy or a known pregnancy (complicated or uncomplicated). The unique features of teenage pregnancy are critical to be familiar with, so as not to miss the diagnosis of pregnancy or identify a complication and initiate timely, appropriate management.
— Ann M. Dietrich, MD, FAAP, FACEP
Introduction and Epidemiology
In 2018, there were 17.4 births per 1,000 adolescent females aged 15-19 years, and 0.2 births per 1,000 females aged 10-14 years.1 Although this has declined significantly during the past decade, teen birth rates in the United States remain higher than in other developed countries.2,3 The decrease in teen pregnancies is largely believed to be secondary to increased contraceptive use, particularly long-acting, reversible contraceptives.4 Additionally, disparities among racial groups persist, with birth rates twice as high in Hispanic and non-Hispanic Black teens and 2.5 times as high in American Indian/Alaskan Native teens as in non-Hispanic whites.1
Other risk factors for teenage pregnancy include depression, history of abortion or prior teenage pregnancy, living with a partner, lower socioeconomic conditions (poverty, unemployment, etc.), and fewer publically funded family clinics in the area. Protective factors include use of contraception and higher levels of education.2, 5,6 Overall outcomes of pregnancies in adolescents (< 20 years of age) in the United States include 25% that are terminated electively, 15% that result in miscarriage, and 61% that result in a birth.7
This article is part one of a two-part narrative discussing the unique features of teenage pregnancy. This article will discuss the social impacts of teenage pregnancy as well as outline key factors in the diagnosis and management of early adolescent pregnancies, including topics such as first-trimester abdominal pain and vaginal bleeding. Part two will focus on obstetrical emergencies in the pregnant adolescent.
Clinical Awareness, Social Impacts, and Importance of Prevention
Teen pregnancy and subsequent childbearing have a significant impact on social and economic factors for both teen parents and their children. Therefore, pregnancy recognition/diagnosis and prevention carry a critical role. Pediatric healthcare providers, including those in the emergency department (ED), should have a low threshold for suspecting pregnancy in adolescents.
Despite this, the diagnosis of teen pregnancy frequently is missed. One study compared the presenting complaints and historical information of pregnant adolescents (≤ 16 years of age) whose diagnosis of pregnancy was made or not made in the ED of a tertiary-care hospital. The researchers found that < 10% of patients who had pregnancy diagnosed mentioned the possibility of pregnancy at initial triage, and 10.5% denied having had sexual activity. Sixty-eight percent of patients whose pregnancy diagnosis was missed had no documentation of their menstrual or sexual history in the chart.8
Teen patients are at increased risk of medical adverse outcomes, including pre-eclampsia, preterm birth, intrauterine fetal growth retardation, and infant death.9-17 Therefore, prompt diagnosis and establishment of prenatal care is critical.
In addition to medical adverse outcomes, there are numerous detrimental social and economic effects of teen pregnancy. Adolescent mothers are less likely to receive a high school diploma or to enroll in college. They also are more likely to live in poverty and face unemployment than women who delay childbearing. Adolescent fathers also are less likely to complete a college education and have been found to earn less income and have higher levels of unemployment.
Children of teen mothers are more likely to have health and cognitive disorders and are more likely to drop out of high school. Female children of teenage mothers are more likely to have an adolescent pregnancy themselves, while male children of teenage mothers have higher rates of incarceration.13,18-22 For the reasons stated, and because 82% of pregnancies in mothers ages 15-19 years are unintentional, prevention of adolescent pregnancy is of substantial importance.23 Emergency medicine clinicians also should be familiar with emergency contraception, both its options and indications.
Emergency contraception is a method of preventing pregnancy after intercourse has occurred. Indications for emergency contraception include any female patient in whom pregnancy is not desired who experienced any of the following: unprotected vaginal sexual intercourse, sexual assault, or vaginal sexual intercourse with concern for contraceptive failure. Generally, the law protects minors in allowing them access to sexual health testing and contraception without parental consent, but laws can be variable, so clinicians should be aware of local protocols. See Table 1 for information regarding emergency contraception options, their timing of use relative to unprotected intercourse, efficacy, and availability.24-28
Table 1. Emergency Contraception24-28 |
|||
|
Contraception |
Timing |
Efficacy |
Availability |
|
Levonorgestrel (Plan B) |
Up to three days after unprotected intercourse |
1.7% to 2.6% pregnancy risk |
Available over the counter |
|
Ulipristal acetate (Ella) |
Up to five days after unprotected intercourse |
1.2% to 1.8% pregnancy risk |
Requires prescription |
|
Copper intrauterine device |
Up to five days after unprotected intercourse, but may be effective at any time in the menstrual cycle when a urine pregnancy test is negative |
0.1% pregnancy risk |
Requires outpatient office visit and clinician insertion (typically not available through the emergency department setting) |
|
Combined oral contraceptives (Dose: 100 mcg to 120 mcg ethinyl estradiol + 0.5 mcg to 0.6 mg levonorgestrel per dose x 2 doses 12 hours apart) |
Up to five days after unprotected intercourse |
11% pregnancy risk |
Requires prescription |
Pregnancy Diagnosis, Initial Steps, and Access to Care
A 17-year-old female presents to the ED with several days of lower abdominal bloating. She has had associated nausea, but no vomiting, and has otherwise been well. She denies any vaginal bleeding or discharge. She is sexually active with one male partner, and she has not been using any contraception. Her last menstrual period was five weeks ago.
There are some unique features to keep in mind when it comes to the diagnosis of pregnancy in adolescents. Adolescent patients may be less forthcoming regarding their suspicion of possible pregnancy, and, therefore, pediatric healthcare providers should routinely collect a menstrual and sexual history on female patients.8 As is true with adult patients, the most common signs and symptoms of early pregnancy include amenorrhea, nausea, breast tenderness, fatigue, weight gain or bloating, and urinary frequency.29
A pregnancy diagnosis typically is confirmed with either urine or serum beta-human chorionic gonadotropin (hCG) testing. While most serum pregnancy tests can detect hCG levels as low as 1-2 mIU/mL, urine pregnancy tests are typically less sensitive, with detection levels beginning at 20-50 mIU/mL.29 Diagnosis, or support thereof, also can be confirmed with a pelvic ultrasound, which will be discussed.
When ordering a pregnancy test, it is important to provide both pre-test and post-test counseling to patients. Pre-test counseling includes notifying the patient that the test will be ordered and also asking the teen how she would feel or what she would do should the test result positive. Parental consent and notification laws vary by state, but nearly every state allows testing for pregnancy without parental consent. Most states also allow women younger than 18 years of age to consent to prenatal care without a parent.30
The first step of post-test counseling is to inform the adolescent of a positive test and elicit her thoughts and feelings about the test result. Adolescents have a wide range of emotions in relation to a positive result, and appropriate resources should be provided, particularly if there is any concern for self-harm. Pregnancy and thoughts of child rearing are an immense time of both emotional and physical change, and for those without adequate support or coping skills, maladaptive coping techniques (substance abuse, overt denial, etc.) can occur. The incidence of pregnancy denial at 20 weeks' gestation is estimated to be one in 475, and the incidence of denial persisting until delivery is one in 2,500. Although there are no direct studies examining the relative incidence in adolescent pregnancies as compared to adult women, pregnancy denial is more common than often thought.31 Denial of pregnancy has been associated with adverse pregnancy outcomes, including lack of prenatal care, precipitous and often unassisted delivery, and fetal abuse or neglect.32 It is important for ED clinicians to have awareness regarding pregnancy denial and, if it is suspected, close outpatient follow-up with both an obstetrician and a psychological/psychiatric team may be indicated.
Sexual Abuse and Adolescent Pregnancy
Clinicians also should have an increased concern for sexual abuse or sex trafficking. One study showed that two-thirds of adolescent women who became pregnant had been sexually abused.33 Another demonstrated that women who had a history of childhood sexual abuse were twice as likely to become pregnant during adolescence.34 Childhood sexual abuse also has been closely associated with post-traumatic stress disorder and substance and alcohol abuse disorders, and it can contribute to other areas of impaired judgment. Asking an adolescent about a history of abuse may allow for early trauma intervention and ultimate improvement in psychosocial and clinical outcomes.
Support, Options, and Follow-up
Despite variation of laws by state requiring notification of parents, it is typically recommended that the patient be encouraged to inform her parent(s) or an adult support person as well as the father of the baby. All available options should be discussed with the patient. This includes predominantly three options: motherhood, abortion, and adoption.35 These options should be at a minimum briefly mentioned and discussed.
Clinicians in the ED often do not have the time or resources to have an extensive conversation regarding options, and therefore a timely referral to another individual who can provide unbiased counseling is important. Adolescents < 15 years of age have been shown to be less likely to obtain prenatal care.36 Helping facilitate prenatal care/early pregnancy resources is advised. Whenever possible, the ED clinician should be the one to physically call and schedule a patient appointment and, at minimum, should provide contact information with a referral.
Substance Abuse in Teen Pregnancy
Rates of unplanned pregnancies are higher in teens who use substances, including tobacco, alcohol, abused prescription opiates, and marijuana, all of which also can be teratogenic to a developing fetus.37 As discussed previously, unintended pregnancies are a higher health risk due to often-delayed pregnancy recognition, resulting in inadequate or delayed prenatal care and fetal exposure to used substances. ED clinicians should evaluate current medications and screen for substance use in all pregnant adolescents. The clinician also should have a discussion regarding the adverse effects of drugs, alcohol, and smoking on both a fetus and the patient herself. The patient should be started on prenatal vitamins. Similarly, if she is on any known teratogenic medications (and the pregnancy is desired or a decision regarding continuation of the pregnancy has not yet been made), instructions should be given for safely discontinuing these medications.Table 2 shows some of the most well-known, common prescription teratogens (this list is not all-inclusive).38
Table 2. Teratogenic Prescription Medications38 |
|
|
Medication Type |
Medications |
|
Neurologic medications (antiepileptics/migraine/psychiatric medications) |
|
|
Antimicrobial medications |
|
|
Anticoagulant medications |
|
|
Antithyroid medications |
|
|
Immunocompromising drugs/chemotherapy |
|
|
Hormonal medications |
|
|
Acne medications |
|
Perinatal and Postpartum Depression
A 17-year-old female, gravidity 1, parity 0, at 32 weeks' gestation presents to the ED with suicidal ideation after thoughts of intentional overdose to end her life. She denies any ingestion or self-harm. She has no prior psychiatric history or inpatient psychiatric admissions. She lives at home with her parents, but she does not feel supported through her pregnancy, and the father of the baby is no longer involved.
Perinatal and postpartum depression can affect any mother or pregnant woman, independent of race, age, education, or income. However, postpartum depression has been shown to be twice as common in adolescent mothers when compared to adults.39 Additionally, adolescents aged 15-19 years who have been diagnosed with a major mental illness have been shown to be nearly three times as likely to have an adolescent pregnancy when compared to those without mental illness.40 In addition to an increased incidence of perinatal and postpartum depression in teens, recognition and access to care often are limited or hindered secondary to a shortage in pediatric psychiatric care, as well as the stigma surrounding teen pregnancy.41
Although less frequent than in the outpatient setting, ED clinicians do encounter pregnant adolescents throughout the perinatal and postpartum period and can serve a key role in identification and potential diagnosis of perinatal mental health issues. ED clinicians should use a validated screening tool for evaluation if there is clinical or patient concern for perinatal depression, such as the Edinburgh Postnatal Depression Scale (viewable online at https://stan.md/304uAyE).42
However, basic screening questions, including assessing for suicidal ideation and home safety, may be warranted with every ED visit in a pregnant adolescent. Early identification can lead to facilitated follow-up for proper intervention by behavioral health specialists.
Intimate Partner Violence During Pregnancy
Approximately 3.2% of women report physical abuse in the form of being pushed, hit, slapped, kicked, choked, or physically hurt by an intimate partner during their most recent pregnancy, and the prevalence of intimate partner violence (IPV) is even higher in teen mothers at nearly 7%.25 IPV has been associated with both adverse maternal and fetal outcomes, including preterm delivery, low birth weight, maternal traumatic injury, and perinatal maternal mental health stressors.6 Therefore, routine screening for IPV is necessary to help identify, and thus reduce, violence and improve outcomes. In the ED, clinicians should routinely ask teen mothers about IPV.
First-Trimester Vaginal Bleeding
A 16-year-old female, gravidity 1, parity 0, at eight weeks' gestation presents to the ED with lower abdominal cramping and vaginal bleeding for the past four hours. She has not yet had an ultrasound during this pregnancy. She is otherwise healthy and has had no prior abdominal surgeries. Vitals signs are within normal limits.
About one-fourth of women will experience some degree of first-trimester vaginal bleeding during pregnancy, and adolescent pregnancies are no exception.43, 44 The differential for first-trimester vaginal bleeding is broad but includes benign nonobstetrical causes (vaginitis, cervicitis, trauma), bleeding in a viable intrauterine pregnancy (threatened abortion), spontaneous abortion (miscarriage), and ectopic pregnancy.45 When it comes to early pregnancy diagnoses, many terms are used. (See Table 3.) Figure 1 displays a diagnostic algorithm for first-trimester vaginal bleeding.
Table 3. Early Pregnancy Diagnoses and Terminology |
|
|
Diagnosis |
Symptom |
|
Threatened abortion |
Vaginal bleeding < 20 weeks' gestation in which there is an ultrasound-confirmed, viable, intrauterine pregnancy with a closed cervix |
|
Viable intrauterine pregnancy |
Intrauterine embryo with cardiac activity and a closed cervix |
|
Intrauterine pregnancy of uncertain viability |
Intrauterine embryo of crown-rump length < 7mm, with closed cervix, and no cardiac activity |
|
Spontaneous abortion |
Spontaneous loss of pregnancy < 20 weeks' gestation
|
|
Embryonic demise/missed abortion |
Embryo with a crown-rump length ≥ 7 mm without cardiac activity |
|
Pregnancy of unknown location |
Positive pregnancy test without an intrauterine or ectopic pregnancy identified on transvaginal ultrasound |
|
Anembryonic gestation |
Gestational sac ≥ 25 mm without a yolk sac or embryo |
|
Ectopic pregnancy |
A pregnancy that is outside of the uterus |
|
Subchorionic hemorrhage |
Blood present between the chorion and the uterine wall |
Figure 1. Diagnostic Algorithm for First-Trimester Vaginal Bleeding45 |
 |
|
TVUS: Transvaginal ultrasound Includes information adapted from Reproductive Health Access Project. First trimester bleeding algorithm. Updated Nov. 1, 2017. https://www.reproductiveaccess.org/resource/first-trimester-bleeding-algorithm/ |
The first step in evaluating a patient presenting with vaginal bleeding is obtaining a thorough history and examination. It is important to obtain information regarding the patient’s menstrual history and whether she has had an ultrasound during this pregnancy. This helps facilitate gestational dating and, importantly, whether the pregnancy is known to be intrauterine. Obtain an obstetrical history with the number of prior pregnancies and births (gravidity and parity — Gs and Ps) and history of complications/outcomes of prior pregnancies. Ask questions to help quantify the amount of bleeding (pads per hour being saturated, the passage of blood clots, and comparison to the patient's normal menstrual period).
Determine the degree and location of pain, if there is any, and whether there are any other associated symptoms concerning for hypovolemia or anemia (e.g., dizziness, syncope, shortness of breath, chest pain). Then, assess vital signs and perform an examination. Signs of hemodynamic instability or peritoneal signs on abdominal examination may indicate the need for prompt evaluation by an obstetrician for emergent surgical intervention. The physical exam should include a speculum exam to evaluate for nonobstetrical causes of bleeding, quantify the degree of bleeding (spotting vs. hemorrhage), and assess for visible products of conception or clots in the cervical os to suggest the diagnosis of incomplete abortion. If there are products of conception present in the os, it is important to remove this tissue because it can help to slow bleeding, and the tissue can be sent to pathology.
Additional laboratory assessment typically is indicated and includes a quantitative beta-hCG level, a pelvic ultrasound, urinalysis, and a type and screen (to determine the patient’s Rhesus [Rh] status). Additional studies may include a complete blood count if there is concern for larger volumes of blood loss and a gonorrhea/chlamydia and wet prep/potassium hydroxide (if indicated per history or examination).
A quantitative beta-hCG level will help to indicate whether an intrauterine pregnancy (IUP) and/or fetal cardiac activity should be visible on ultrasound. The discriminatory level of beta-hCG is the hormone level at which an IUP should be seen on transvaginal ultrasound.46 This level varies with the type of ultrasound machine and skill set of the ultrasonographer; however, it is typically considered to be ~1,500 mIU/mL.47,48 Even if the beta-hCG level is < 1,500 mIU/mL, the pelvic ultrasound still is indicated to evaluate for signs of ectopic pregnancy (adnexal mass, free fluid in the cul-de-sac). This is crucial because ectopic pregnancies can have beta-HCG values well below the discriminatory level.
A positive pregnancy test with an empty uterus and the presence of free fluid in the right upper quadrant (RUQ) on ultrasonography is highly concerning for ectopic pregnancy and warrants an emergent obstetrical consultation. An ED/point-of-care ultrasound of the RUQ in a patient where there is concern for ectopic can greatly reduce the time to diagnosis and therefore prompt treatment.49 The progression of ultrasound findings in early pregnancy, as well as concerning ultrasound findings for ectopic pregnancy, are shown in Figure 2.50
Figure 2. Ultrasonography Findings of Early Pregnancy69 |
 |
|
RUQ: Right upper quadrant. Images courtesy of Viveta Lobo, MD. |
Pregnancy of Unknown Location
A pregnancy of unknown location describes the scenario when a patient has a positive pregnancy test, but no evidence of IUP or ectopic pregnancy on ultrasonography. For these patients, in-depth discussions regarding monitoring of symptoms and ectopic return precautions (i.e., worsened pain, increased bleeding, dizziness, syncope) should be discussed in conjunction with an obstetrical (OB) consultation. Additionally, serial quantitative beta-hCG testing and repeat ultrasounds are indicated until a definitive diagnosis can be made.
Intrauterine Pregnancy of Unknown Viability
An intrauterine pregnancy of unknown viability describes the scenario when a patient has vaginal bleeding, a confirmed IUP on ultrasound, but no detection of fetal cardiac activity. The patient’s beta-hCG level and the size of the embryo can help indicate whether this is likely to be a missed abortion vs. an early IUP that will go on to be a viable pregnancy. A beta-hCG level of > 5,000-6,500 mIU/mL and a crown-rump length of ≥ 7 mm are more suggestive of a missed abortion.51 Unless there is definitive evidence of a missed abortion as suggestive above, repeat ultrasound should be performed in seven to 10 days to confirm viability.45
Threatened Abortion
A threatened abortion describes the scenario when a patient has vaginal bleeding, but a confirmed viable IUP on ultrasound. Once fetal cardiac activity has been confirmed on ultrasonography, the risk of spontaneous abortion decreases significantly to approximately 11%, but detection of a subchorionic hemorrhage can increase this risk despite presence the of cardiac activity.52,53 Management of threatened abortion includes discussions regarding bleeding precautions (more than two pads per hour for more than two hours or development of dizziness, chest pain, shortness of breath, or syncope), routine outpatient obstetrician follow-up, and repeat ultrasound if bleeding continues.
Types of Spontaneous Abortions: Incomplete, Inevitable, Missed, and Anembryonic Gestation
Spontaneous abortion describes the scenario when a patient has an IUP on ultrasound but no fetal cardiac activity despite either a previous ultrasound showing cardiac activity or an embryo with crown-rump length ≥ 7 mm. In these cases, there are typically three options for management (expectant, medical, and surgical), and physicians should counsel patients and use shared decision making in conjunction with an OB consultant to guide management choice.
Patient mental health and complication risk are similar among all three treatments.54,55
- Expectant management is watchful waiting and letting the pregnancy pass without any further interventions. This typically is effective for incomplete abortion; however, it is less effective for missed abortions.56
- Medical management includes administering medications (typically 800 mcg intravaginal misoprostol
± 200 mg oral mifepristone). Although it has not been shown to increase completion rates for incomplete abortions, it is more effective than expectant management for missed abortions.57, 58 - Surgical management typically is performed by uterine vacuum aspiration, which is an office-based procedure that usually allows for less uncertainty in terms of completion and fewer days of bleeding.
All patients should be offered contraception with outpatient follow-up after early pregnancy loss.
Ectopic Pregnancy
Ectopic pregnancy describes the scenario when a patient has an adnexal mass or extrauterine embryo confirmed by ultrasound or free fluid in the cul-de-sac (along with the absence of an IUP when otherwise normally expected) in the presence of a positive pregnancy test. Keep in mind that an IUP on ultrasonography requires the presence of both an intrauterine gestational sac and yolk sac.
Without the presence of a yolk sac or fetal pole, the fluid-filled structure could be a pseudo-gestational sac that can be seen with ectopic pregnancy. The incidence in the United States is 1% to 2%, and 6% of maternal deaths are due to ruptured ectopic pregnancies.59 Risk factors for ectopic pregnancy include previous ectopic pregnancy, tubal surgery, intrauterine device use, in vitro fertilization in current pregnancy, previous sexually transmitted infections or pelvic inflammatory disease, and tobacco use/smoking.60-66
Similar to spontaneous abortion, there are three management options for ectopic pregnancy (expectant, medical, and surgical) in conjunction with an OB consultant. The criteria for each are described below:
- Expectant: beta-hCG level
< 1,000 mIU/mL, ectopic mass
< 3 cm with no fetal cardiac activity, minimal pain or bleeding, no evidence of rupture, patient reliable for follow-up care.67– Extensive counseling and surveillance with repeat beta-hCG levels every 48 hours to confirm decreasing levels and then every week until negative.68
- Medical: beta-hCG level
< 2,000 mIU/mL, ectopic mass
≤ 3.5 cm with no fetal cardiac activity, minimal symptoms with stable vital signs, no evidence of rupture, patient reliable for follow-up care.– Intramuscular methotrexate, followed by trending of beta-hCG levels.47
- Surgical: advanced ectopic (high beta-hCG, large mass, fetal cardiac activity), contraindications to methotrexate, signs of rupture or severe symptoms, unreliability for follow-up care.
– Salpingectomy or salpingostomy.
Finally, an Rh status should be determined with vaginal bleeding during early pregnancy. Although the risk of alloimmunization is low (1.5% to 2%), patients with an Rh-negative status should receive Rho(D) immune globulin (Rhogam) within 72 hours of pregnancy loss at a dose of 120 mcg to 300 mcg.69 There are insufficient data for or against the use of Rhogam in threatened abortion.
Hyperemesis Gravidarum
A 15-year-old female, gravidity 1, parity 0, at 10 weeks' gestation presents to the ED with persistent nausea and vomiting, unable to tolerate oral intake. She reports > 10 episodes of non-bloody, non-bilious emesis today. She denies any fever, diarrhea, or vaginal bleeding or discharge. She has had nausea and intermittent vomiting most of her pregnancy, but symptoms have worsened over the past few days.
Approximately 75% of pregnant women will have some degree of nausea with or without vomiting during early pregnancy.70,71 The onset of nausea typically is between four and six weeks' gestation, with a peak around weeks nine through 12. For the majority of women, these symptoms resolve by mid-pregnancy. 70 For most, these symptoms are not severe enough to affect daily life.
However, 0.3% to 2% of pregnant women develop hyperemesis gravidarum, a condition that is characterized by severe vomiting that results in weight loss of
> 5%, ketonuria, electrolyte abnormalities, and dehydration that are refractory to standard outpatient medical treatment.70 These patients often will require admission for intravenous fluid hydration.
Risk factors for hyperemesis gravidarum include both fetal and maternal factors, as described in Table 4.72,73 Maternal complications of hyperemesis gravidarum include Wernicke’s encephalopathy, central pontine myelinolysis, acute tubular necrosis, Mallory-Weiss tears, pneumomediastinum, splenic avulsion, and social/psychological impacts (anxiety, depression, lost work time).74-76 On presentation, patients with hyperemesis gravidarum present with severe vomiting and associated symptoms, such as weight loss, orthostasis, and presyncope. Common exam findings often include signs of dehydration, including tachycardia, positive orthostatic vital signs, dry mucous membranes, and poor skin turgor.
Table 4. Risk Factors for Hyperemesis Gravidarum |
|
|
Fetal-Related Risk Factors |
Maternal-Related Risk Factors |
|
|
It is important to remember that hyperemesis gravidarum is a diagnosis of exclusion and, therefore, a broad differential should be considered. Other causes of vomiting in pregnancy may include gastroenteritis, gastroparesis, biliary colic or cholecystitis, pancreatitis, appendicitis, pyelonephritis, ovarian torsion, diabetic ketoacidosis; migraine headaches; preeclampsia, hemolysis, elevated liver enzymes, and low platelet count; acute fatty liver of pregnancy; and molar pregnancy.77-79
Molar pregnancies are a rare abnormal pregnancy that results from aberrant fertilization. They are more common among maternal extremes of age, including ≤ 15 years. Molar pregnancies typically result in higher serum beta-hCG levels and are associated with a higher prevalence of hyperemesis gravidarum.80 These pregnancies carry a risk of becoming locally invasive in the uterus and can metastasize, causing malignant disease.81
Diagnostic workup often includes urinalysis, complete metabolic panel, and serum quantitative beta-hCG and thyroid stimulating hormone. Imaging is not typically indicated unless there is clinical concern for a molar pregnancy or an alternative etiology of vomiting that would require imaging for diagnosis. Laboratory abnormalities commonly seen with hyperemesis gravidarum include a hypokalemic, hypochloremic metabolic alkalosis, ketonuria, transaminitis with liver function tests typically two to three times the upper normal limit, and hemoconcentration.7 The treatment approach for vomiting in pregnancy is multimodal, including dietary modifications, over-the-counter medications, prescribed medications, and parenteral fluids and nutrition for refractory cases. Figure 3 discusses management options and indications for these therapeutic interventions.71,78 Patients with evidence of laboratory abnormalities and/or who are unable to tolerate oral intake despite administration of antiemetics and glucose-containing fluids may warrant obstetrics consultation for admission.
Figure 3. Therapeutic Interventions for Nausea and Vomiting in Pregnancy |
 |
Conclusion
Teen pregnancy remains relatively prevalent in the United States when compared to other developed countries. It is crucial that pediatric acute care clinicians understand pregnancy-related complications and management.
An additional focus of pregnancy in the adolescent population should be an impetus on counseling and prevention, given the significant social and economic adverse impacts of teen pregnancy. Several high-risk conditions are at least equally, if not more, prevalent in adolescent mothers than in adult mothers, including pregnancy denial, substance use disorders, sexual assault and intimate partner violence, and peripartum and postpartum depression. It is important that ED clinicians be aware of these conditions and ensure that deliberate screening, counseling, and arrangement of appropriate follow-up is performed routinely from the ED.
Two of the most common pregnancy-related presentations to the ED include first-trimester vaginal bleeding and nausea and vomiting. ED clinicians should be well-informed on the clinical presentation, risk factors, diagnostic work-up, and management of these conditions.
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Acute care providers will frequently encounter an adolescent with a new diagnosis of pregnancy or a known pregnancy (complicated or uncomplicated). The unique features of teenage pregnancy are critical to be familiar with, so as not to miss the diagnosis of pregnancy or identify a complication and initiate timely, appropriate management.
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