Fluoroquinolones such as ciprofloxacin, levofloxacin, and moxifloxacin have been associated with retinal detachment since the publication of the large, case-control study in 2012. A new study challenges that finding, suggesting fluoroquinolones do not increase the risk of retinal detachment. The new study was a nationwide, register-based cohort from Denmark from 1997-2011 that included nearly 750,000 episodes of fluoroquinolone use, the majority of which was ciprofloxacin. The study looked at recent and past use of the drugs up to 180 days prior. They found that “fluoroquinolone use was not associated with an increased risk of retinal detachment.” This included current users, recent users (past month), or past users of the drugs (up to 6 months). Almost 90% of the participants in the study used ciprofloxacin, so the results are primarily applicable to that drug (JAMA2013;310:2184-2190).
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