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In an attempt to clarify criteria for diagnosing adrenal insufficiency in patients with severe sepsis and septic shock, this group of French investigators serially performed both the cosyntropin stimulation test and the metyrapone stimulation test in 2 cohorts of such patients, and compared the findings with those from concurrent ICU patients without sepsis as well as a group of healthy volunteers.

Diagnosing Adrenal Insufficiency in Sepsis