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Treatment of dyslipidemia with statins produces consistent, durable lowering of low-density lipoprotein cholesterol (LDL-C), which is associated with substantial reductions in myocardial infarction and stroke.
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Short (< 7 hours/night) sleep duration is associated with increased BMI and increased genetic influences on BMI. Longer sleep duration may reduce genetic influences on body weight.
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A completely synthetic, once-monthly, erythropoiesis-stimulating agent has been approved for the treatment of anemia in dialysis patients.
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A historical cohort study from San Francisco General Hospital evaluated patients ≥18 years old that were hospitalized and received at least one dose of ceftriaxone. In a multivariable analysis, for every day a patient also received doxycycline the rate of Clostridium difficile infection was 27% lower than for those who did not receive doxycycline (hazard ratio, 0.73%; 95% confidence interval, 0.56-0.96).
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Small subcortical brain infarcts, known as lacunar strokes, account for about 25% of all ischemic strokes.
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Two men presented to a hospital in northwestern Missouri in June 2009 with fever, fatigue, diarrhea, thrombocytopenia and leukopenia. Both had a history of frequent recent tick bites. A novel phlebovirus was isolated in cell culture from patient blood. Electron microscopy revealed virus particles consistent with Bunyaviridae. Sequencing identified the viruses as novel members of the phlebovirus genus.
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Patients who present with acute myocardial infarction (MI) complicated by cardiogenic shock represent a group at high risk for early mortality. Current guidelines recommend the use of intra-aortic balloon pump (IABP) for these patients, but there are few randomized, controlled trial data to support this.
