Browse OB/GYN Clinical Alert Articles by Topic

Is a Vacuum-Induced Device Effective for Control of Postpartum Hemorrhage?

In this multicenter study across 12 centers in the United States, a vacuum-induced intrauterine device successfully treated 94% of participants who experienced a postpartum hemorrhage with a median time of three minutes to control of bleeding.

Anticholinergic Use for Three Months or More Increases Dementia Risk

There is a significant increase in dementia risk associated with the use of anticholinergic medications for three months or longer.

Does Maternal BMI Influence the Success of Trial of Labor After Cesarean?

In this retrospective cohort study between May 2007 and April 2016, women undergoing a trial of labor after cesarean (TOLAC) were analyzed to determine if pre-pregnancy or delivery obesity status made an impact on TOLAC success. Overall, maternal body mass index did not have a significant effect on TOLAC success rates.

Tranexamic Acid for the Prevention of Obstetric Hemorrhage

In this prospective, cohort, pharmacokinetic-pharmacodynamic (PKPD) dose-finding study by Ahmadzia and colleagues, 30 pregnant women (10 women in each study arm) received 5 mg/kg, 10 mg/kg, or 15 mg/kg doses of tranexamic acid for the prevention of postpartum hemorrhage. Advanced PKPD modeling demonstrated that 600 mg of tranexamic acid was the optimal dose to use in the prevention of postpartum hemorrhage.

HIV Management During Pregnancy

Human immunodeficiency virus (HIV) infection during pregnancy carries a significant burden to healthcare systems, and continues to be of significant public health concern.

The Cost-Effectiveness of HPV Vaccination for Adults Aged 30 to 45 Years

This study evaluated the cost-effectiveness of extending the upper age limit of human papillomavirus (HPV) vaccination to age 30 to 45 years using two independent HPV microsimulation models and found that vaccinating in this age group was not cost-effective.

Are Modern Intrauterine Devices Associated with Infertility?

In this prospective cohort study of 461 women, there was no association between intrauterine device use and time to conception (hazard ratio, 1.25; 95% confidence interval, 0.99-1.58). However, past Mycoplasma genitalium infection was found to be associated with longer times to conception and lower conception rates by 12 months (68% vs. 80%, P = 0.02).

The Levonorgestrel IUD Is Similarly Effective as the Copper IUD for Emergency Contraception

In this randomized, noninferiority trial among patients seeking emergency contraception after at least one episode of unprotected intercourse within five days of presentation, the levonorgestrel 52-mg intrauterine device (IUD) was noninferior to the copper T30A IUD at preventing pregnancy one month after IUD insertion. Adverse events between the two groups were similar.

Does Prescription of Contraception During the Postpartum Hospitalization Affect Postpartum Visit Adherence?

In this retrospective cohort study of 1,015 women at one institution, there was no association between type of contraceptive prescribed immediately postpartum and attendance at the postpartum visit.

Is it Safe to Discharge Patients Without an Opioid Prescription After Gynecologic Surgery?

In this quality improvement initiative study, patients undergoing scheduled gynecologic abdominal surgery via both minimally invasive and open routes were able to be discharged safely without a prescription of opioids without significant increases in postoperative calls about pain or the need for filling opioid prescriptions after discharge.