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There is a known association of obesity and glucose intolerance with pancreatic cancer but whether this is due to the effect of high glucose itself, insulin resistance, or pancreatic ß-cell dysfunction is unknown.
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An irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) has been approved for first-line treatment of non-small cell lung cancer (NSCLC) with certain EGFR mutations.
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High-sensitivity cardiac troponin (hs-cTn) assays have higher sensitivity for myocardial ischemic injury and necrosis than conventional assays, but with reduced specificity.
An hs-cTn level below the detectable limit is very accurate at excluding AMI in an ED patient with chest pain.
The precision of hs-cTn assays enables serial sampling of cardiac biomarkers to exclude AMI to be done over 1-2 hours as opposed to 3-9 hours for conventional cTn assays.
A normal coronary CT angiography (CCTA) (< 50% stenosis in any epicardial coronary artery) performed in an ED patient with chest pain is associated with a good 30-day outcome.
Use of CCTA in ED patients with chest pain is associated with reduced length of stay, admissions, and overall costs compared to typical care that often involves myocardial perfusion imaging.
CCTA is associated with a small but consistent increase in invasive coronary angiograms and reperfusion procedures compared to typical care that often involved myocardial perfusion imaging.
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This small proof-of-concept study suggests that yoga may be helpful in patients with highly symptomatic, long-standing paroxysmal atrial fibrillation.
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A case-control study of women in the Nurses Health Study Cohort showed that lower melatonin secretion is independently associated with a higher risk of developing type 2 diabetes. There is a physiologic basis for this finding since melatonin has a role in glucose metabolism and lack of melatonin is associated with increased insulin resistance.
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