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The fda has approved the first naloxone hand-held auto-injector. It is intended for family members or caregivers to treat suspected opioid overdose. The auto-injector can be carried in a pocket or stored in a medicine cabinet. The product was reviewed under the agencys priority review program. It is marketed by Kaleo, Inc. as Evzio.
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Bendopnea, which is defined as shortness of breath when bending over, has been found to be a dominant symptom in patients with heart failure. It appears to be caused by a further increase in filling pressures when bending over in patients with heart failure, especially when filling pressures are already high and the cardiac index is reduced.
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In a study of veterans with no recent history of depression or opioid use, the risk of developing depression increased as the duration of opioid analgesic exposure increased.
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The authors concluded that vitamin D supplementation in patients with fibromyalgia syndrome (FMS) and low levels of vitamin D might be an economical, safe, and effective therapy for patients with FMS.
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Mesial temporal sclerosis is the most common pathology found in surgical series of patients undergoing temporal lobectomy for pharmacologically intractable focal epilepsy. A better understanding of the mechanisms leading to this neuropathological substrate for temporal lobe epilepsy should provide fundamental insights into the pathophysiology of epileptogenesis.
